Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia

Mohd Hafiz Ngoo Abdullah, Zulhabri Othman, Hamdan Mohd Noor, Siti Suri Arshad, Ahmad Khairuddin Mohd Yusof, A. Rahman A. Jamal, Abdul Rashid Abdul Rahman

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The molecular basis of coronary artery disease (CAD) has been widely studied in the western world but there is no published work on the Malaysian population. This study looked at the global gene expression profiling of the peripheral blood of patients with CAD from the 3 main ethnic groups in Malaysia. Male subjects selected were based on angiographically confirmed CAD (≥50% stenosis) and normal control subjects (0% stenosis) with age range of 55.6. ± 5.3 and 51.0. ± 5.5. years, respectively. The global gene expression of 12 angiographically documented CAD patients and 11 matched control subjects were performed. The combined group samples identified 6 up regulated differential expression (DE) genes (GHRL, LTA, CBS, HP, ITGA2B, and OLR1) and 12 down regulated DE genes (IL18R1, ITGA2B, IL18RAP, HP, OLR1, SOD2 ITGB3, IL1B, MMP9, PLA2G7, UTS2, and CBS) to be involved in CAD at the fold change of 1.3 with fault discovery rate (FDR) of 1%. Three genes, MMP9, IL1B, and SOD2 were down regulated in all the 3 ethnic groups making them potential biomarker candidates for CAD across all three ethnicities. Further verification in a cohort study is needed.

Original languageEnglish
Pages (from-to)192-203
Number of pages12
JournalJournal of Cardiology
Volume60
Issue number3
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Malaysia
Transcriptome
Coronary Artery Disease
Gene Expression
Ethnic Groups
Pathologic Constriction
Western World
Gene Expression Profiling
Cohort Studies
Biomarkers
Population
Genes

Keywords

  • Coronary artery disease
  • Gene expression
  • IL1B
  • Malaysia
  • MMP9
  • SOD2

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia. / Abdullah, Mohd Hafiz Ngoo; Othman, Zulhabri; Noor, Hamdan Mohd; Arshad, Siti Suri; Yusof, Ahmad Khairuddin Mohd; A. Jamal, A. Rahman; Rahman, Abdul Rashid Abdul.

In: Journal of Cardiology, Vol. 60, No. 3, 09.2012, p. 192-203.

Research output: Contribution to journalArticle

Abdullah, Mohd Hafiz Ngoo ; Othman, Zulhabri ; Noor, Hamdan Mohd ; Arshad, Siti Suri ; Yusof, Ahmad Khairuddin Mohd ; A. Jamal, A. Rahman ; Rahman, Abdul Rashid Abdul. / Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia. In: Journal of Cardiology. 2012 ; Vol. 60, No. 3. pp. 192-203.
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