Pathology, genetics and cytogenetics of Wilms' tumour

Reena Rahayu Md Zain, Ashleigh Murch, Adrian Charles

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Wilms' tumour (WT) is an embryonal cancer of childhood and is thought to be derived from embryonic kidney precursor cells. The Knudson two hit model was initially thought to occur in WT, but findings emerging from genetic and cytogenetic studies in the past two decades have implicated several genetic events. Recent techniques in genetic analysis have improved our ability to characterise changes in genes involved in WT which include WT1, CTNNB1, IGF2 and WTX. These genetic events have not only provided insight into the pathobiology of this malignancy, but the recognition of these candidate genes may offer potential targets for novel therapies. In this review, we will provide an overview of the pathological, genetic and cytogenetic characteristics of WT.

Original languageEnglish
Pages (from-to)302-312
Number of pages11
JournalPathology
Volume43
Issue number4
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Fingerprint

Wilms Tumor
Cytogenetics
Pathology
Genetic Techniques
Germ Cell and Embryonal Neoplasms
Genes
Kidney
Neoplasms
Therapeutics

Keywords

  • Cytogenetics
  • Genetics
  • Pathology
  • Wilms' tumour

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Pathology, genetics and cytogenetics of Wilms' tumour. / Md Zain, Reena Rahayu; Murch, Ashleigh; Charles, Adrian.

In: Pathology, Vol. 43, No. 4, 06.2011, p. 302-312.

Research output: Contribution to journalReview article

Md Zain, Reena Rahayu ; Murch, Ashleigh ; Charles, Adrian. / Pathology, genetics and cytogenetics of Wilms' tumour. In: Pathology. 2011 ; Vol. 43, No. 4. pp. 302-312.
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