Pathogenesis of epilepsy

Challenges in animal models

Yow Hui Yin, Nurulumi Ahmad, Mohd Makmor Bakry

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, several investigations have embarked on advancing knowledge of the mechanism underlying epileptogenesis, understanding in mechanism of pharmacoresistance and discovering antiepileptogenic or disease-modifying therapy. Animal models play a crucial and significant role in providing additional insight into mechanism of epileptogenesis. With the help of these models, epileptogenesis process has been demonstrated to be involved in various molecular and biological pathways or processes. Hence, this article will discuss the known and postulated mechanisms of epileptogenesis and challenges in using the animal models.

Original languageEnglish
Pages (from-to)1119-1132
Number of pages14
JournalIranian Journal of Basic Medical Sciences
Volume16
Issue number11
Publication statusPublished - Nov 2013

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Epilepsy
Animals
Animal Models
Anticonvulsants
Therapeutics

Keywords

  • Animal models
  • Epileptogenesis
  • Pathogenesis of epilepsy
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Biochemistry
  • Biophysics
  • Clinical Biochemistry
  • Drug Discovery

Cite this

Pathogenesis of epilepsy : Challenges in animal models. / Yin, Yow Hui; Ahmad, Nurulumi; Makmor Bakry, Mohd.

In: Iranian Journal of Basic Medical Sciences, Vol. 16, No. 11, 11.2013, p. 1119-1132.

Research output: Contribution to journalArticle

Yin, Yow Hui ; Ahmad, Nurulumi ; Makmor Bakry, Mohd. / Pathogenesis of epilepsy : Challenges in animal models. In: Iranian Journal of Basic Medical Sciences. 2013 ; Vol. 16, No. 11. pp. 1119-1132.
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