Particles trajectories simulation of hydrodynamic focusing in circular and rectangular polymer microflow cytometer

Norasyikin Selamat, Muhammad Syafiq Bin Rahim, Abang Annuar Ehsan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hydrodynamic focusing is an important method used in microfluidics cell sorting devices. It is a technique that allows two sheath fluids to conflow at different velocities to obtain the focusing of sample fluid. The objective of hydrodynamic focusing is to make sure the particle arrives one by one at detection source. Simulation is done using COMSOL Multyphysics software to observe particle trajectories in micro flow cytometer with circular and rectangular cross-section. The density and sizes of the particles is similar to protein particles properties. Normal inflow velocity fot sheath channel is 800µm/s and normal inflow velocity for sample channel is 150µm/s. At The beginning of the experiment, circular flow cytometer was expected to have better hydrodynamic focusing effect and better particle trajectories. However, after the simulation is done the results show that particle trajectories in rectangular channel are better. Reduce channel height is one of the factor that enables particle to focus in the middle of the channel for the rectangular shape channel device.

Original languageEnglish
Pages (from-to)1311-1315
Number of pages5
JournalInternational Journal of Applied Engineering Research
Volume12
Issue number7
Publication statusPublished - 2017

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Hydrodynamics
Trajectories
Polymers
Fluids
Sorting
Microfluidics
Cells
Proteins
Experiments

Keywords

  • COMSOL
  • Hydrodynamic focusing
  • Microflow cytometer
  • Microfluidics

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Particles trajectories simulation of hydrodynamic focusing in circular and rectangular polymer microflow cytometer. / Selamat, Norasyikin; Rahim, Muhammad Syafiq Bin; Ehsan, Abang Annuar.

In: International Journal of Applied Engineering Research, Vol. 12, No. 7, 2017, p. 1311-1315.

Research output: Contribution to journalArticle

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