Parkia speciosa empty pod prevents hypertension and cardiac damage in rats given N(G)-nitro-L-arginine methyl ester

Kamisah Yusof, Japar Sidik Fadhlullah Zuhair, Abdul Hamid Juliana, Kamsiah Jaarin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Parkia speciosa Hassk is a plant found abundantly in Southeast Asia region. Its seeds with or without pods and roots have been used in traditional medicine in this region to treat hypertension. Therefore, we aimed to investigate the potential effect of the plant empty pod extract on hypertension development and changes in heart induced by N(G)-nitro-L-arginine methyl ester (L-NAME) administration in rats. Twenty-four male Sprague Dawley rats were divided into four groups. Groups 1 to 3 were given L-NAME (25 mg/kg, intraperitoneally) for 8 weeks. Groups 2 and 3 were also given Parkia speciosa empty pods methanolic extract (800 mg/kg, orally) and nicardipine (3 mg/kg, orally), concurrently with L-NAME. The last group served as the control. L-NAME reduced plasma nitric oxide level and therefore, increased systolic blood pressure, angiotensin-converting enzyme and NADPH oxidase activities as well as lipid peroxidation in the heart. Parkia speciosa extract and nicardipine treatments had significantly prevented the elevations of blood pressure, angiotensin-converting enzyme, NADPH oxidase activities and lipid peroxidation in the heart induced by the L-NAME. Parkia speciosa extract but not nicardipine prevented the reduction in plasma nitric oxide level caused by L-NAME. In conclusion, Parkia speciosa empty pods methanolic extract has a potential to prevent the development of hypertension possibly by preventing the loss of plasma nitric oxide, as well as has cardioprotective effects by reducing angiotensin-converting enzyme activity and oxidative stress in the heart in rats administered L-NAME.

Original languageEnglish
Pages (from-to)291-298
Number of pages8
JournalBiomedicine and Pharmacotherapy
Volume96
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

NG-Nitroarginine Methyl Ester
Hypertension
Nicardipine
Peptidyl-Dipeptidase A
Nitric Oxide
NADPH Oxidase
Blood Pressure
Lipid Peroxidation
Southeastern Asia
Traditional Medicine
Sprague Dawley Rats
Seeds
Oxidative Stress

Keywords

  • Angiotensin-converting enzyme
  • Hypertension
  • L-NAME
  • NADPH oxidase
  • Petai papan

ASJC Scopus subject areas

  • Pharmacology

Cite this

Parkia speciosa empty pod prevents hypertension and cardiac damage in rats given N(G)-nitro-L-arginine methyl ester. / Yusof, Kamisah; Zuhair, Japar Sidik Fadhlullah; Juliana, Abdul Hamid; Jaarin, Kamsiah.

In: Biomedicine and Pharmacotherapy, Vol. 96, 01.12.2017, p. 291-298.

Research output: Contribution to journalArticle

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