PARK16 is associated with PD in the Malaysian population

Aroma Agape Gopalai, Azlina Ahmad-Annuar, Hui Hua Li, Yi Zhao, Shen Yang Lim, Ai Huey Tan, Thien Thein Lim, Gaik Bee Eow, Puvanarajah Santhi, Viswanathan Shanthi, Norlinah Mohamed Ibrahim, Zariah Abdul Aziz, Soo Kun Lim, Chong Tin Tan, Eng King Tan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

PARK16 was identified as a risk factor for Parkinson's disease in a Japanese cohort; however, subsequent studies in the other populations including the Chinese, European, Caucasian, and Chilean have shown a protective role instead. To investigate this locus in our Malaysian cohort, 1,144 individuals were screened for five SNPs in the PARK16 locus and logistic regression analysis showed that the A allele of the rs947211 SNP reduced the risk of developing PD via a recessive model (Odds ratio 0.57, P-value 0.0003). Pooled analysis with other Asian studies showed that A allele of the rs947211 SNP decreased the risk of developing PD via a recessive model (Odds ratio 0.71, P-value 0.0001). In addition, when meta-analysis was performed with other Asian population, three SNPs (rs823128, rs823156, and rs11240572) reduced risk of developing PD via a dominant model.

Original languageEnglish
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Single Nucleotide Polymorphism
Population
Alleles
Odds Ratio
Parkinson Disease
Meta-Analysis
Logistic Models
Regression Analysis
Parkinson Disease 16

Keywords

  • Genetics
  • Malaysia
  • Meta-analysis
  • PARK16
  • Parkinson's disease

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Gopalai, A. A., Ahmad-Annuar, A., Li, H. H., Zhao, Y., Lim, S. Y., Tan, A. H., ... Tan, E. K. (Accepted/In press). PARK16 is associated with PD in the Malaysian population. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. https://doi.org/10.1002/ajmg.b.32454

PARK16 is associated with PD in the Malaysian population. / Gopalai, Aroma Agape; Ahmad-Annuar, Azlina; Li, Hui Hua; Zhao, Yi; Lim, Shen Yang; Tan, Ai Huey; Lim, Thien Thein; Eow, Gaik Bee; Santhi, Puvanarajah; Shanthi, Viswanathan; Mohamed Ibrahim, Norlinah; Aziz, Zariah Abdul; Lim, Soo Kun; Tan, Chong Tin; Tan, Eng King.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 2016.

Research output: Contribution to journalArticle

Gopalai, AA, Ahmad-Annuar, A, Li, HH, Zhao, Y, Lim, SY, Tan, AH, Lim, TT, Eow, GB, Santhi, P, Shanthi, V, Mohamed Ibrahim, N, Aziz, ZA, Lim, SK, Tan, CT & Tan, EK 2016, 'PARK16 is associated with PD in the Malaysian population', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. https://doi.org/10.1002/ajmg.b.32454
Gopalai, Aroma Agape ; Ahmad-Annuar, Azlina ; Li, Hui Hua ; Zhao, Yi ; Lim, Shen Yang ; Tan, Ai Huey ; Lim, Thien Thein ; Eow, Gaik Bee ; Santhi, Puvanarajah ; Shanthi, Viswanathan ; Mohamed Ibrahim, Norlinah ; Aziz, Zariah Abdul ; Lim, Soo Kun ; Tan, Chong Tin ; Tan, Eng King. / PARK16 is associated with PD in the Malaysian population. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2016.
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AU - Lim, Thien Thein

AU - Eow, Gaik Bee

AU - Santhi, Puvanarajah

AU - Shanthi, Viswanathan

AU - Mohamed Ibrahim, Norlinah

AU - Aziz, Zariah Abdul

AU - Lim, Soo Kun

AU - Tan, Chong Tin

AU - Tan, Eng King

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AB - PARK16 was identified as a risk factor for Parkinson's disease in a Japanese cohort; however, subsequent studies in the other populations including the Chinese, European, Caucasian, and Chilean have shown a protective role instead. To investigate this locus in our Malaysian cohort, 1,144 individuals were screened for five SNPs in the PARK16 locus and logistic regression analysis showed that the A allele of the rs947211 SNP reduced the risk of developing PD via a recessive model (Odds ratio 0.57, P-value 0.0003). Pooled analysis with other Asian studies showed that A allele of the rs947211 SNP decreased the risk of developing PD via a recessive model (Odds ratio 0.71, P-value 0.0001). In addition, when meta-analysis was performed with other Asian population, three SNPs (rs823128, rs823156, and rs11240572) reduced risk of developing PD via a dominant model.

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