Pancreatic gene variants potentially associated with dipeptidyl peptidase-4 inhibitor treatment response in Type 2 diabetes

Jazlina Liza Jamaluddin, Hasniza Zaman Huri, Shireene Ratna Vethakkan, Norlaila Mustafa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the adult pancreas, the expression of the genes PAX4, KCNQ1, TCF7L2, KCNJ11, ABCC8, MTNR1B and WFS1 are mainly restricted to cells to maintain glucose homeostasis. We have identified these genes as the main regulators of incretin-mediated actions, and therefore they may potentially influence the response of DPP-4 inhibitors. This review represents the first detailed exploration of pancreatic -cell genes and their variant mechanisms, which could potentially affect the response of DPP-4 inhibitors in Type 2 diabetes. We have focused on the signaling pathways of these genes to understand their roles in gastrointestinal incretin-mediated effects; and finally, we sought to associate gene mechanisms with their Type 2 diabetes risk variants to predict the responses of DPP-4 inhibitors for this disease.

Original languageEnglish
Pages (from-to)235-249
Number of pages15
JournalPharmacogenomics
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Dipeptidyl-Peptidase IV Inhibitors
Type 2 Diabetes Mellitus
Incretins
Genes
Pancreas
Homeostasis
Gene Expression
Glucose

Keywords

  • ABCC8
  • dipeptidyl peptidase-4 inhibitors
  • KCNJ11
  • KCNQ1
  • MTNR1B
  • PAX4
  • TCF7L2
  • WFS1

ASJC Scopus subject areas

  • Pharmacology
  • Genetics
  • Molecular Medicine
  • Medicine(all)

Cite this

Pancreatic gene variants potentially associated with dipeptidyl peptidase-4 inhibitor treatment response in Type 2 diabetes. / Jamaluddin, Jazlina Liza; Huri, Hasniza Zaman; Vethakkan, Shireene Ratna; Mustafa, Norlaila.

In: Pharmacogenomics, Vol. 15, No. 2, 02.2014, p. 235-249.

Research output: Contribution to journalArticle

Jamaluddin, Jazlina Liza ; Huri, Hasniza Zaman ; Vethakkan, Shireene Ratna ; Mustafa, Norlaila. / Pancreatic gene variants potentially associated with dipeptidyl peptidase-4 inhibitor treatment response in Type 2 diabetes. In: Pharmacogenomics. 2014 ; Vol. 15, No. 2. pp. 235-249.
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