PAMAM dendrimers as promising nanocarriers for RNAi therapeutics

Prashant Kesharwani, Sanjeev Banerjee, Umesh Gupta, Mohd Cairul Iqbal Mohd Amin, Subhash Padhye, Fazlul H. Sarkar, Arun K. Iyer

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Therapeutics based on RNA interference mechanisms are highly promising for the management of several diseases including multi-drug resistant cancers. However, effective delivery of siRNAs and oligonucleotides still remains challenging. In this regard, hyper-branched, PAMAM dendrimers having unique three-dimensional architecture and nanoscale size, with cationic surface charge can potentially serve as siRNA condensing agents as well as robust nano-vectors for targeted delivery. In addition, their surface functionality permits conjugation of drugs and genes or development of hybrid systems for combination therapy. Thus far, in vitro cellular testing of dendrimer-mediated siRNA delivery has revealed great potential, with reports on their in vivo effectiveness starting to appear. These favorable outcomes portend a promising future for dendrimer mediated RNAi therapeutics.

Original languageEnglish
JournalMaterials Today
DOIs
Publication statusAccepted/In press - 2015

Fingerprint

Dendrimers
dendrimers
Small Interfering RNA
delivery
drugs
Surface charge
Hybrid systems
Oligonucleotides
Pharmaceutical Preparations
condensing
oligonucleotides
Genes
RNA
conjugation
genes
therapy
Testing
cancer
interference
PAMAM Starburst

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Kesharwani, P., Banerjee, S., Gupta, U., Mohd Amin, M. C. I., Padhye, S., Sarkar, F. H., & Iyer, A. K. (Accepted/In press). PAMAM dendrimers as promising nanocarriers for RNAi therapeutics. Materials Today. https://doi.org/10.1016/j.mattod.2015.06.003

PAMAM dendrimers as promising nanocarriers for RNAi therapeutics. / Kesharwani, Prashant; Banerjee, Sanjeev; Gupta, Umesh; Mohd Amin, Mohd Cairul Iqbal; Padhye, Subhash; Sarkar, Fazlul H.; Iyer, Arun K.

In: Materials Today, 2015.

Research output: Contribution to journalArticle

Kesharwani, Prashant ; Banerjee, Sanjeev ; Gupta, Umesh ; Mohd Amin, Mohd Cairul Iqbal ; Padhye, Subhash ; Sarkar, Fazlul H. ; Iyer, Arun K. / PAMAM dendrimers as promising nanocarriers for RNAi therapeutics. In: Materials Today. 2015.
@article{317ef3c4c4c345d69e7b0e1d823bf090,
title = "PAMAM dendrimers as promising nanocarriers for RNAi therapeutics",
abstract = "Therapeutics based on RNA interference mechanisms are highly promising for the management of several diseases including multi-drug resistant cancers. However, effective delivery of siRNAs and oligonucleotides still remains challenging. In this regard, hyper-branched, PAMAM dendrimers having unique three-dimensional architecture and nanoscale size, with cationic surface charge can potentially serve as siRNA condensing agents as well as robust nano-vectors for targeted delivery. In addition, their surface functionality permits conjugation of drugs and genes or development of hybrid systems for combination therapy. Thus far, in vitro cellular testing of dendrimer-mediated siRNA delivery has revealed great potential, with reports on their in vivo effectiveness starting to appear. These favorable outcomes portend a promising future for dendrimer mediated RNAi therapeutics.",
author = "Prashant Kesharwani and Sanjeev Banerjee and Umesh Gupta and {Mohd Amin}, {Mohd Cairul Iqbal} and Subhash Padhye and Sarkar, {Fazlul H.} and Iyer, {Arun K.}",
year = "2015",
doi = "10.1016/j.mattod.2015.06.003",
language = "English",
journal = "Materials Today",
issn = "1369-7021",
publisher = "Elsevier",

}

TY - JOUR

T1 - PAMAM dendrimers as promising nanocarriers for RNAi therapeutics

AU - Kesharwani, Prashant

AU - Banerjee, Sanjeev

AU - Gupta, Umesh

AU - Mohd Amin, Mohd Cairul Iqbal

AU - Padhye, Subhash

AU - Sarkar, Fazlul H.

AU - Iyer, Arun K.

PY - 2015

Y1 - 2015

N2 - Therapeutics based on RNA interference mechanisms are highly promising for the management of several diseases including multi-drug resistant cancers. However, effective delivery of siRNAs and oligonucleotides still remains challenging. In this regard, hyper-branched, PAMAM dendrimers having unique three-dimensional architecture and nanoscale size, with cationic surface charge can potentially serve as siRNA condensing agents as well as robust nano-vectors for targeted delivery. In addition, their surface functionality permits conjugation of drugs and genes or development of hybrid systems for combination therapy. Thus far, in vitro cellular testing of dendrimer-mediated siRNA delivery has revealed great potential, with reports on their in vivo effectiveness starting to appear. These favorable outcomes portend a promising future for dendrimer mediated RNAi therapeutics.

AB - Therapeutics based on RNA interference mechanisms are highly promising for the management of several diseases including multi-drug resistant cancers. However, effective delivery of siRNAs and oligonucleotides still remains challenging. In this regard, hyper-branched, PAMAM dendrimers having unique three-dimensional architecture and nanoscale size, with cationic surface charge can potentially serve as siRNA condensing agents as well as robust nano-vectors for targeted delivery. In addition, their surface functionality permits conjugation of drugs and genes or development of hybrid systems for combination therapy. Thus far, in vitro cellular testing of dendrimer-mediated siRNA delivery has revealed great potential, with reports on their in vivo effectiveness starting to appear. These favorable outcomes portend a promising future for dendrimer mediated RNAi therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=84937459937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937459937&partnerID=8YFLogxK

U2 - 10.1016/j.mattod.2015.06.003

DO - 10.1016/j.mattod.2015.06.003

M3 - Article

AN - SCOPUS:84937459937

JO - Materials Today

JF - Materials Today

SN - 1369-7021

ER -