Palm vitamin eprotects bone against dexamethasone-induced osteoporosis in male rats

Ima Nirwana Soelaiman, H. Fakhrurazi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The aim of this study was to determine the effects of palm oil-derived vitamin E on glucocorticoid-induced osteoporosis. Three-month old male Wistar rats were adrenalectomised to remove circulating glucocorticoids. The animals were then administered with Dexamethasone 120 µg/kg body weight/day. Treatment with palm vitamin E 60 mg/kg body weight/day was given simultaneously. The results showed that palm vitamin E prevented the loss in regional and whole body bone mineral density seen in the Dexamethasone treated animals. Palm vitamin E improved femoral length and calcium content in the Dexamethasone treated animals. The results confirmed that palm oil-derived vitamin E was effective in preventing glucocorticoid-induced osteoporosis.

Original languageEnglish
Pages (from-to)136-144
Number of pages9
JournalThe Medical journal of Malaysia
Volume57
Issue number2
Publication statusPublished - 1 Jun 2002

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Vitamin E
Vitamins
Dexamethasone
Osteoporosis
Bone and Bones
Glucocorticoids
Body Weight
Thigh
Bone Density
Wistar Rats
Calcium
palm oil

ASJC Scopus subject areas

  • Medicine(all)

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Palm vitamin eprotects bone against dexamethasone-induced osteoporosis in male rats. / Soelaiman, Ima Nirwana; Fakhrurazi, H.

In: The Medical journal of Malaysia, Vol. 57, No. 2, 01.06.2002, p. 136-144.

Research output: Contribution to journalArticle

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