Palm vitamin E reduces catecholamines, xanthine oxidase activity and gastric lesions in rats exposed to water-immersion restraint stress

Nur Azlina Mohd Fahami, Ibrahim AbdelAziz Ibrahim, Kamisah Yusof, Nafeeza Mohd Ismail

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22 Citations (Scopus)

Abstract

Background: This study examined the effects of Palm vitamin E (PVE) and α-tocopherol (α-TF) supplementations on adrenalin, noradrenalin, xanthine oxidase plus dehydrogenase (XO + XD) activities and gastric lesions in rats exposed to water-immersion restraint stress (WIRS).Methods: Sixty male Sprague-Dawley rats (200-250 g) were randomly divided into three equal sized groups. The control group was given a normal diet, while the treated groups received the same diet with oral supplementation of PVE or α-TF at 60 mg/kg body weight. After the treatment period of 28 days, each group was further subdivided into two groups with 10 rats without exposing them to stress and the other 10 rats were subjected to WIRS for 3.5 hours. Blood samples were taken to measure the adrenalin and noradrenalin levels. The rats were then sacrificed following which the stomach was excised and opened along the greater curvature and examined for lesions and XO + XD activities.Results: The rats exposed to WIRS had lesions in their stomach mucosa. Our findings showed that dietary supplementations of PVE and α-TF were able to reduce gastric lesions significantly in comparison to the stressed control group. WIRS increased plasma adrenalin and noradrenalin significantly. PVE and α-TF treatments reduced these parameters significantly compared to the stressed control.Conclusions: Supplementations with either PVE or α-TF reduce the formation of gastric lesions. Their protective effect was related to their abilities to inhibit stress induced elevation of adrenalin and noradrenalin levels as well as through reduction in xanthine oxidase and dehydrogenase activities.

Original languageEnglish
Article number54
JournalBMC Gastroenterology
Volume12
DOIs
Publication statusPublished - 28 May 2012

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Xanthine Oxidase
Immersion
Vitamin E
Catecholamines
Stomach
Epinephrine
Norepinephrine
Water
Xanthine Dehydrogenase
Diet
Control Groups
Tocopherols
Dietary Supplements
Sprague Dawley Rats
Oxidoreductases
Mucous Membrane
Body Weight

ASJC Scopus subject areas

  • Gastroenterology

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Palm vitamin E reduces catecholamines, xanthine oxidase activity and gastric lesions in rats exposed to water-immersion restraint stress. / Mohd Fahami, Nur Azlina; Ibrahim, Ibrahim AbdelAziz; Yusof, Kamisah; Ismail, Nafeeza Mohd.

In: BMC Gastroenterology, Vol. 12, 54, 28.05.2012.

Research output: Contribution to journalArticle

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