Palm vitamin E protects against ferric-nitriltrioacetate-induced impairment of bone calcification

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Abstract

Young growing male rats (age four weeks) were subjected to the toxic effects of ferric nitrilotriacetate, a powerful oxidant, for eight weeks. Concomitantly administration of two doses (30 and 60 mg/kg rat weight) of the vitamin E-rich extract of palm oil containing the antioxidants tocopherol and tocotrienols on the effects on bone growth and calcification were studied. The femur was selected to represent cortical bone, and the lumbar vertebrae to represent cancellous bone. Daily intraperitoneal injections of ferric nitrilotriacetate, 2 mg/kg rat weight significantly impaired calcification of the femoral bone. Giving palm vitamin E 60 mg/kg rat weight orally was successful in preventing the impairment. This effect was not seen in the lumbar vertebrae. Other parameters, i.e. bone mineral density, bone ash weight, femur length and serum alkaline phosphatase and tartrate-resistant acid phosphatase did not show any significant changes. Overall weight gain was also not depressed by ferric nitrilotriacetate and no significant changes were seen upon giving palm vitamin E. No significant changes were seen with palm vitamin E 30 mg/kg rat weight. In conclusion, ferric nitrilotriacetate were found to inhibit cortical bone calcification in young growing rats. Palm vitamin E 60 mg/kg rat weight was found to significantly prevent this inhibition.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalAsia Pacific Journal of Pharmacology
Volume13
Issue number1
Publication statusPublished - 1998

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Vitamin E
Bone and Bones
Weights and Measures
Lumbar Vertebrae
Femur
Tocotrienols
Tocopherols
Poisons
Bone Development
Thigh
Intraperitoneal Injections
Oxidants
Bone Density
Weight Gain
Alkaline Phosphatase
Antioxidants
ferric nitrilotriacetate
Serum

Keywords

  • Bone
  • Fe-NTA
  • Palm vitamin E
  • Tocopherol
  • Tocotrienols

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "Young growing male rats (age four weeks) were subjected to the toxic effects of ferric nitrilotriacetate, a powerful oxidant, for eight weeks. Concomitantly administration of two doses (30 and 60 mg/kg rat weight) of the vitamin E-rich extract of palm oil containing the antioxidants tocopherol and tocotrienols on the effects on bone growth and calcification were studied. The femur was selected to represent cortical bone, and the lumbar vertebrae to represent cancellous bone. Daily intraperitoneal injections of ferric nitrilotriacetate, 2 mg/kg rat weight significantly impaired calcification of the femoral bone. Giving palm vitamin E 60 mg/kg rat weight orally was successful in preventing the impairment. This effect was not seen in the lumbar vertebrae. Other parameters, i.e. bone mineral density, bone ash weight, femur length and serum alkaline phosphatase and tartrate-resistant acid phosphatase did not show any significant changes. Overall weight gain was also not depressed by ferric nitrilotriacetate and no significant changes were seen upon giving palm vitamin E. No significant changes were seen with palm vitamin E 30 mg/kg rat weight. In conclusion, ferric nitrilotriacetate were found to inhibit cortical bone calcification in young growing rats. Palm vitamin E 60 mg/kg rat weight was found to significantly prevent this inhibition.",
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