Palm vitamin E prevents osteoporosis in orchidectomized growing male rats

Ima Nirwana Soelaiman, A. Kiftiah, A. G. Zainal, Norazlina Mohamed, M. T. Gapor, B. A K Khalid

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Testosterone deficiency increased bone resorption, giving rise to osteoporosis. Testosterone deficiency also increased lipid peroxidation and free radical formation. Free radicals have been shown to be toxic to osteoblasts as well as to activate osteoclasts. In this study, the effects of giving an antioxidant, i.e, vitamin E-rich extract from palm oil on bone mineral density and calcium content was studied. Palm vitamin E prevented the loss in bone mineral density due to orchidectomy, seen in the whole femur, proximal and midshaft regions, as well as L4 vertebra, Similar observations were seen in bone calcium content of the L5 vertebra. Giving palm olein also prevented the loss in bone mineral density in the femoral midshaft and LA vertebra; and bone calcium content in the L5 vertebra. In conclusion, vitamin E-rich extract from palm oil was effective in preventing the loss in bone mineral density and calcium content of orchidectomized male rats. This action is probably due to its role as an antioxidant.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalNatural Product Sciences
Volume6
Issue number4
Publication statusPublished - 2000

Fingerprint

Vitamin E
Bone Density
Osteoporosis
Rats
Bone
Spine
Calcium
Minerals
Free Radicals
Testosterone
Antioxidants
Bone and Bones
Orchiectomy
Poisons
Osteoclasts
Bone Resorption
Thigh
Osteoblasts
Femur
Lipid Peroxidation

Keywords

  • Bone mineral density
  • Orchidectomy
  • Palm vitamin E
  • Testosterone

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Soelaiman, I. N., Kiftiah, A., Zainal, A. G., Mohamed, N., Gapor, M. T., & Khalid, B. A. K. (2000). Palm vitamin E prevents osteoporosis in orchidectomized growing male rats. Natural Product Sciences, 6(4), 155-160.

Palm vitamin E prevents osteoporosis in orchidectomized growing male rats. / Soelaiman, Ima Nirwana; Kiftiah, A.; Zainal, A. G.; Mohamed, Norazlina; Gapor, M. T.; Khalid, B. A K.

In: Natural Product Sciences, Vol. 6, No. 4, 2000, p. 155-160.

Research output: Contribution to journalArticle

Soelaiman, IN, Kiftiah, A, Zainal, AG, Mohamed, N, Gapor, MT & Khalid, BAK 2000, 'Palm vitamin E prevents osteoporosis in orchidectomized growing male rats', Natural Product Sciences, vol. 6, no. 4, pp. 155-160.
Soelaiman, Ima Nirwana ; Kiftiah, A. ; Zainal, A. G. ; Mohamed, Norazlina ; Gapor, M. T. ; Khalid, B. A K. / Palm vitamin E prevents osteoporosis in orchidectomized growing male rats. In: Natural Product Sciences. 2000 ; Vol. 6, No. 4. pp. 155-160.
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AU - Khalid, B. A K

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