Palm vitamin E and glucosamine sulphate in the treatment of osteoarthritis of the knee

Nor Hazla Mohamed Haflah, Kamsiah Jaarin, Suhail Abdullah, Masbah Omar

Research output: Contribution to journalArticle

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Abstract

Objectives: To assess the efficacy of oral palm vitamin E in reducing symptoms of patients with osteoarthritis (OA) of the knee compared to oral glucosamine sulphate. Methods: This open study was carried out at the Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia between March 2006 and November 2007. Seventy-nine patients were recruited to receive either 1.5g oral glucosamine sulphate or 400mg oral palm vitamin E for 6 months. Symptoms were assessed using the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index and visual analogue scale (VAS). Results: Sixty-four patients completed the trial (vitamin E n=33, glucosamine sulfate n=31). After 6 months of treatment, both groups showed a significant improvement in WOMAC scale and significant reduction in the VAS score during standing and walking. There was no significant difference in WOMAC scale and VAS score between the 2 groups. Except for mild allergic reaction and abdominal discomfort in one patient, there were no other serious adverse effects reported. Serum malondialdehyde was significantly higher in the glucosamine group compared to palm vitamin E treated group at the end of the study. Serum of vitamin E was significantly higher in the palm vitamin E group compared to glucosamine. Conclusion: The finding of this study suggests that oral palm vitamin E in a dose of 400mg taken daily has a potential role in reducing symptoms of patients with OA of the knee. It may be just as effective as glucosamine sulphate in reducing the symptoms and free from serious side effects. Further study is required to ascertain the mechanism of action beside its antioxidant effect.

Original languageEnglish
Pages (from-to)1432-1438
Number of pages7
JournalSaudi Medical Journal
Volume30
Issue number11
Publication statusPublished - Nov 2009

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Knee Osteoarthritis
Glucosamine
Vitamin E
Visual Analog Scale
Malaysia
Therapeutics
Ontario
Malondialdehyde
Serum
Osteoarthritis
Walking
Hypersensitivity
Antioxidants

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Palm vitamin E and glucosamine sulphate in the treatment of osteoarthritis of the knee. / Mohamed Haflah, Nor Hazla; Jaarin, Kamsiah; Abdullah, Suhail; Omar, Masbah.

In: Saudi Medical Journal, Vol. 30, No. 11, 11.2009, p. 1432-1438.

Research output: Contribution to journalArticle

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abstract = "Objectives: To assess the efficacy of oral palm vitamin E in reducing symptoms of patients with osteoarthritis (OA) of the knee compared to oral glucosamine sulphate. Methods: This open study was carried out at the Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia between March 2006 and November 2007. Seventy-nine patients were recruited to receive either 1.5g oral glucosamine sulphate or 400mg oral palm vitamin E for 6 months. Symptoms were assessed using the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index and visual analogue scale (VAS). Results: Sixty-four patients completed the trial (vitamin E n=33, glucosamine sulfate n=31). After 6 months of treatment, both groups showed a significant improvement in WOMAC scale and significant reduction in the VAS score during standing and walking. There was no significant difference in WOMAC scale and VAS score between the 2 groups. Except for mild allergic reaction and abdominal discomfort in one patient, there were no other serious adverse effects reported. Serum malondialdehyde was significantly higher in the glucosamine group compared to palm vitamin E treated group at the end of the study. Serum of vitamin E was significantly higher in the palm vitamin E group compared to glucosamine. Conclusion: The finding of this study suggests that oral palm vitamin E in a dose of 400mg taken daily has a potential role in reducing symptoms of patients with OA of the knee. It may be just as effective as glucosamine sulphate in reducing the symptoms and free from serious side effects. Further study is required to ascertain the mechanism of action beside its antioxidant effect.",
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