Palm tocotrienol-rich fraction supplementation suppressed stress-induced gastric oxidative stress in rats

Kamisah Yusof, A. A I Ibrahim, M. I. Nafeeza, Nur Azlina Mohd Fahami

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Palm tocotrienol-rich fraction (TRF), an extract from palm oil containing both tocotrienol and tocopherol, is known for its antioxidant effect. The present study investigated the effect of palm TRF on the stomach using a water immersion restraint stress (WRS) model. Fortytwo male Sprague-Dawley rats were divided into three groups and were administered 60 mg/kg/d of palm TRF, a-tocopherol or vehicle only for 28 days. At the end of the treatment period, half of the rats from each group were subjected to WRS for 3.5 hours, after which the rats were sacrificed. The stomachs were then examined for lesions and measured for thiobarbituric acid reactive substance content and xanthine oxidase activity. Rats exposed to WRS showed gastric mucosal lesions. Pretreatments of the palm TRF and a-tocopherol reduced the occurrence of the lesions. WRS also increased gastric malondialdehyde content and xanthine oxidase activity significantly, but the increase in the oxidative stress parameters were significantly suppressed by both vitamin E pretreatments. However, the effects of palm TRF and a-tocopherol on the parameters measured were not different. In conclusion, palm TRF has the ability to protect against gastric mucosal injury, likely via its ability to inhibit oxidative stress.

Original languageEnglish
Pages (from-to)118-122
Number of pages5
JournalJournal of Applied Pharmaceutical Science
Volume1
Issue number10
Publication statusPublished - Dec 2011

Fingerprint

Tocotrienols
Stomach
Oxidative Stress
Tocopherols
Immersion
Water
Xanthine Oxidase
Gastrointestinal Contents
Thiobarbituric Acid Reactive Substances
Malondialdehyde
Vitamin E
Sprague Dawley Rats
Antioxidants
Wounds and Injuries

Keywords

  • Gastric lesion
  • Lipid peroxidation
  • Tocotrienol
  • Water immersion restraint stress
  • Xanthine oxidase

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medicine (miscellaneous)
  • Pharmacology (medical)

Cite this

Palm tocotrienol-rich fraction supplementation suppressed stress-induced gastric oxidative stress in rats. / Yusof, Kamisah; Ibrahim, A. A I; Nafeeza, M. I.; Mohd Fahami, Nur Azlina.

In: Journal of Applied Pharmaceutical Science, Vol. 1, No. 10, 12.2011, p. 118-122.

Research output: Contribution to journalArticle

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