Palladium-mediated intracellular chemistry

Muhammad Rahimi Usop, Asier Unciti-Broceta, Emma M V Johansson, Rosario M. Sánchez-Martín, Mark Bradley

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

Many important intracellular biochemical reactions are modulated by transition metals, typically in the form of metalloproteins. The ability to carry out selective transformations inside a cell would allow researchers to manipulate or interrogate innumerable biological processes. Here, we show that palladium nanoparticles trapped within polystyrene microspheres can enter cells and mediate a variety of Pd0-catalysed reactions, such as allylcarbamate cleavage and Suzuki-Miyaura cross-coupling. The work provides the basis for the customization of heterogeneous unnatural catalysts as tools to carry out artificial chemistries within cells. Such in cellulo synthesis has potential for a plethora of applications ranging from cellular labelling to synthesis of modulators or inhibitors of cell function.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalNature Chemistry
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Palladium
Metalloproteins
Polystyrenes
Microspheres
Labeling
Modulators
Transition metals
Nanoparticles
Catalysts

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Usop, M. R., Unciti-Broceta, A., Johansson, E. M. V., Sánchez-Martín, R. M., & Bradley, M. (2011). Palladium-mediated intracellular chemistry. Nature Chemistry, 3(3), 239-243. https://doi.org/10.1038/nchem.981

Palladium-mediated intracellular chemistry. / Usop, Muhammad Rahimi; Unciti-Broceta, Asier; Johansson, Emma M V; Sánchez-Martín, Rosario M.; Bradley, Mark.

In: Nature Chemistry, Vol. 3, No. 3, 03.2011, p. 239-243.

Research output: Contribution to journalArticle

Usop, MR, Unciti-Broceta, A, Johansson, EMV, Sánchez-Martín, RM & Bradley, M 2011, 'Palladium-mediated intracellular chemistry', Nature Chemistry, vol. 3, no. 3, pp. 239-243. https://doi.org/10.1038/nchem.981
Usop MR, Unciti-Broceta A, Johansson EMV, Sánchez-Martín RM, Bradley M. Palladium-mediated intracellular chemistry. Nature Chemistry. 2011 Mar;3(3):239-243. https://doi.org/10.1038/nchem.981
Usop, Muhammad Rahimi ; Unciti-Broceta, Asier ; Johansson, Emma M V ; Sánchez-Martín, Rosario M. ; Bradley, Mark. / Palladium-mediated intracellular chemistry. In: Nature Chemistry. 2011 ; Vol. 3, No. 3. pp. 239-243.
@article{81b592ffeb6b4694967adabd94125df9,
title = "Palladium-mediated intracellular chemistry",
abstract = "Many important intracellular biochemical reactions are modulated by transition metals, typically in the form of metalloproteins. The ability to carry out selective transformations inside a cell would allow researchers to manipulate or interrogate innumerable biological processes. Here, we show that palladium nanoparticles trapped within polystyrene microspheres can enter cells and mediate a variety of Pd0-catalysed reactions, such as allylcarbamate cleavage and Suzuki-Miyaura cross-coupling. The work provides the basis for the customization of heterogeneous unnatural catalysts as tools to carry out artificial chemistries within cells. Such in cellulo synthesis has potential for a plethora of applications ranging from cellular labelling to synthesis of modulators or inhibitors of cell function.",
author = "Usop, {Muhammad Rahimi} and Asier Unciti-Broceta and Johansson, {Emma M V} and S{\'a}nchez-Mart{\'i}n, {Rosario M.} and Mark Bradley",
year = "2011",
month = "3",
doi = "10.1038/nchem.981",
language = "English",
volume = "3",
pages = "239--243",
journal = "Nature Chemistry",
issn = "1755-4330",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Palladium-mediated intracellular chemistry

AU - Usop, Muhammad Rahimi

AU - Unciti-Broceta, Asier

AU - Johansson, Emma M V

AU - Sánchez-Martín, Rosario M.

AU - Bradley, Mark

PY - 2011/3

Y1 - 2011/3

N2 - Many important intracellular biochemical reactions are modulated by transition metals, typically in the form of metalloproteins. The ability to carry out selective transformations inside a cell would allow researchers to manipulate or interrogate innumerable biological processes. Here, we show that palladium nanoparticles trapped within polystyrene microspheres can enter cells and mediate a variety of Pd0-catalysed reactions, such as allylcarbamate cleavage and Suzuki-Miyaura cross-coupling. The work provides the basis for the customization of heterogeneous unnatural catalysts as tools to carry out artificial chemistries within cells. Such in cellulo synthesis has potential for a plethora of applications ranging from cellular labelling to synthesis of modulators or inhibitors of cell function.

AB - Many important intracellular biochemical reactions are modulated by transition metals, typically in the form of metalloproteins. The ability to carry out selective transformations inside a cell would allow researchers to manipulate or interrogate innumerable biological processes. Here, we show that palladium nanoparticles trapped within polystyrene microspheres can enter cells and mediate a variety of Pd0-catalysed reactions, such as allylcarbamate cleavage and Suzuki-Miyaura cross-coupling. The work provides the basis for the customization of heterogeneous unnatural catalysts as tools to carry out artificial chemistries within cells. Such in cellulo synthesis has potential for a plethora of applications ranging from cellular labelling to synthesis of modulators or inhibitors of cell function.

UR - http://www.scopus.com/inward/record.url?scp=79951964610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951964610&partnerID=8YFLogxK

U2 - 10.1038/nchem.981

DO - 10.1038/nchem.981

M3 - Article

C2 - 21336331

AN - SCOPUS:79951964610

VL - 3

SP - 239

EP - 243

JO - Nature Chemistry

JF - Nature Chemistry

SN - 1755-4330

IS - 3

ER -