Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

Wei Ge, Alexander Wolf, Tianshu Feng, Chia Hua Ho, Rok Sekirnik, Adam Zayer, Nicolas Granatino, Matthew E. Cockman, Christoph Loenarz, Nikita D. Loik, Adam P. Hardy, Timothy D W Claridge, Refaat B. Hamed, Rasheduzzaman Chowdhury, Lingzhi Gong, Carol V. Robinson, David C. Trudgian, Miao Jiang, Muhammad Mukram Mohamed Mackeen, James S. McCullaghYuliya Gordiyenko, Armin Thalhammer, Atsushi Yamamoto, Ming Yang, Phebee Liu-Yi, Zhihong Zhang, Marion Schmidt-Zachmann, Benedikt M. Kessler, Peter J. Ratcliffe, Gail M. Preston, Mathew L. Coleman, Christopher J. Schofield

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

The finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription raises questions as to whether the translation machinery and prokaryotic proteins are analogously modified. Escherichia coli ycfD is a growth-regulating 2-oxoglutarate oxygenase catalyzing arginyl hydroxylation of the ribosomal protein Rpl16. Human ycfD homologs, Myc-induced nuclear antigen (MINA53) and NO66, are also linked to growth and catalyze histidyl hydroxylation of Rpl27a and Rpl8, respectively. This work reveals new therapeutic possibilities via oxygenase inhibition and by targeting modified over unmodified ribosomes.

Original languageEnglish
Pages (from-to)960-962
Number of pages3
JournalNature Chemical Biology
Volume8
Issue number12
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

Fingerprint

Oxygenases
Hydroxylation
Ribosomes
Nuclear Antigens
Ribosomal Proteins
Growth
Proteins
Escherichia coli
Therapeutics

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Ge, W., Wolf, A., Feng, T., Ho, C. H., Sekirnik, R., Zayer, A., ... Schofield, C. J. (2012). Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nature Chemical Biology, 8(12), 960-962. https://doi.org/10.1038/nchembio.1093

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. / Ge, Wei; Wolf, Alexander; Feng, Tianshu; Ho, Chia Hua; Sekirnik, Rok; Zayer, Adam; Granatino, Nicolas; Cockman, Matthew E.; Loenarz, Christoph; Loik, Nikita D.; Hardy, Adam P.; Claridge, Timothy D W; Hamed, Refaat B.; Chowdhury, Rasheduzzaman; Gong, Lingzhi; Robinson, Carol V.; Trudgian, David C.; Jiang, Miao; Mohamed Mackeen, Muhammad Mukram; McCullagh, James S.; Gordiyenko, Yuliya; Thalhammer, Armin; Yamamoto, Atsushi; Yang, Ming; Liu-Yi, Phebee; Zhang, Zhihong; Schmidt-Zachmann, Marion; Kessler, Benedikt M.; Ratcliffe, Peter J.; Preston, Gail M.; Coleman, Mathew L.; Schofield, Christopher J.

In: Nature Chemical Biology, Vol. 8, No. 12, 12.2012, p. 960-962.

Research output: Contribution to journalArticle

Ge, W, Wolf, A, Feng, T, Ho, CH, Sekirnik, R, Zayer, A, Granatino, N, Cockman, ME, Loenarz, C, Loik, ND, Hardy, AP, Claridge, TDW, Hamed, RB, Chowdhury, R, Gong, L, Robinson, CV, Trudgian, DC, Jiang, M, Mohamed Mackeen, MM, McCullagh, JS, Gordiyenko, Y, Thalhammer, A, Yamamoto, A, Yang, M, Liu-Yi, P, Zhang, Z, Schmidt-Zachmann, M, Kessler, BM, Ratcliffe, PJ, Preston, GM, Coleman, ML & Schofield, CJ 2012, 'Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans', Nature Chemical Biology, vol. 8, no. 12, pp. 960-962. https://doi.org/10.1038/nchembio.1093
Ge, Wei ; Wolf, Alexander ; Feng, Tianshu ; Ho, Chia Hua ; Sekirnik, Rok ; Zayer, Adam ; Granatino, Nicolas ; Cockman, Matthew E. ; Loenarz, Christoph ; Loik, Nikita D. ; Hardy, Adam P. ; Claridge, Timothy D W ; Hamed, Refaat B. ; Chowdhury, Rasheduzzaman ; Gong, Lingzhi ; Robinson, Carol V. ; Trudgian, David C. ; Jiang, Miao ; Mohamed Mackeen, Muhammad Mukram ; McCullagh, James S. ; Gordiyenko, Yuliya ; Thalhammer, Armin ; Yamamoto, Atsushi ; Yang, Ming ; Liu-Yi, Phebee ; Zhang, Zhihong ; Schmidt-Zachmann, Marion ; Kessler, Benedikt M. ; Ratcliffe, Peter J. ; Preston, Gail M. ; Coleman, Mathew L. ; Schofield, Christopher J. / Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. In: Nature Chemical Biology. 2012 ; Vol. 8, No. 12. pp. 960-962.
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