Oxygen-air mixture does not differ from oxygen-nitrous oxide mixture in influencing PF ratio in healthy patients undergoing laparoscopic cholecystectomy

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Abstract

Objective: This randomized single-blind study was designed to evaluate the effects of oxygen administration in air versus in N2O to the PaO 2 / FiO2 (PF ratio) in healthy patients undergoing laparoscopic cholecystectomy. Method: Sixteen patients with ASA I and II, age of less than 65 years and BMI of less than 40 were randomly recruited into two groups to receive either O2 in air gas mixture (Group 1) or O 2 in N2O gas mixture (Group 2). All patients received midazolam 7.5 mg po and 3 minutes preoxygenation with 100% O2 prior to the induction of anaesthesia. Anaesthesia was induced with IV fentanyl 2 mcg/kg, propofol 2 mg/kg and paralyzed with IV rocuronium 0.6-0.8 mg/kg. All patients were maintained with FiO2 of 0.35, sevoflurane with MAC of 1.0-1.2 and end CO2 of 30-35 mmHg. Result: The peritoneal insufflations pressures were documented. A series of blood gases were taken prior to preoxygenation, at 30, 60 and 90 minutes post intubation. There was no overall difference between the two groups in terms of the PF ratio (p = 0.142), over time (p = 0.515) and time interaction within groups (p = 0.806) despite lower overall PF ratio in Group 2. Conclusion: There was no significant difference in the partial pressure of oxygen to the fractional inspired oxygen ratio (PF Ratio) in healthy patients ventilated with oxygen-Air or oxygen-nitrous oxide mixtures during laparoscopic cholecyctectomy.

Original languageEnglish
Pages (from-to)205-207
Number of pages3
JournalInternational Medical Journal
Volume17
Issue number3
Publication statusPublished - Sep 2010

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Laparoscopic Cholecystectomy
Nitrous Oxide
Air
Oxygen
Gases
Anesthesia
Single-Blind Method
Insufflation
Partial Pressure
Midazolam
Fentanyl
Propofol
Intubation
Pressure

Keywords

  • Fractional inspired
  • Nitrous oxide
  • Oxygen-air
  • Partial pressure oxygen
  • PF ratio

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Oxygen-air mixture does not differ from oxygen-nitrous oxide mixture in influencing PF ratio in healthy patients undergoing laparoscopic cholecystectomy",
abstract = "Objective: This randomized single-blind study was designed to evaluate the effects of oxygen administration in air versus in N2O to the PaO 2 / FiO2 (PF ratio) in healthy patients undergoing laparoscopic cholecystectomy. Method: Sixteen patients with ASA I and II, age of less than 65 years and BMI of less than 40 were randomly recruited into two groups to receive either O2 in air gas mixture (Group 1) or O 2 in N2O gas mixture (Group 2). All patients received midazolam 7.5 mg po and 3 minutes preoxygenation with 100{\%} O2 prior to the induction of anaesthesia. Anaesthesia was induced with IV fentanyl 2 mcg/kg, propofol 2 mg/kg and paralyzed with IV rocuronium 0.6-0.8 mg/kg. All patients were maintained with FiO2 of 0.35, sevoflurane with MAC of 1.0-1.2 and end CO2 of 30-35 mmHg. Result: The peritoneal insufflations pressures were documented. A series of blood gases were taken prior to preoxygenation, at 30, 60 and 90 minutes post intubation. There was no overall difference between the two groups in terms of the PF ratio (p = 0.142), over time (p = 0.515) and time interaction within groups (p = 0.806) despite lower overall PF ratio in Group 2. Conclusion: There was no significant difference in the partial pressure of oxygen to the fractional inspired oxygen ratio (PF Ratio) in healthy patients ventilated with oxygen-Air or oxygen-nitrous oxide mixtures during laparoscopic cholecyctectomy.",
keywords = "Fractional inspired, Nitrous oxide, Oxygen-air, Partial pressure oxygen, PF ratio",
author = "Abdullah, {Normah Binti} and {Abdul Rahman}, Raha and Muhammad Maaya and {Md Zain}, Jaafar",
year = "2010",
month = "9",
language = "English",
volume = "17",
pages = "205--207",
journal = "International Medical Journal",
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T1 - Oxygen-air mixture does not differ from oxygen-nitrous oxide mixture in influencing PF ratio in healthy patients undergoing laparoscopic cholecystectomy

AU - Abdullah, Normah Binti

AU - Abdul Rahman, Raha

AU - Maaya, Muhammad

AU - Md Zain, Jaafar

PY - 2010/9

Y1 - 2010/9

N2 - Objective: This randomized single-blind study was designed to evaluate the effects of oxygen administration in air versus in N2O to the PaO 2 / FiO2 (PF ratio) in healthy patients undergoing laparoscopic cholecystectomy. Method: Sixteen patients with ASA I and II, age of less than 65 years and BMI of less than 40 were randomly recruited into two groups to receive either O2 in air gas mixture (Group 1) or O 2 in N2O gas mixture (Group 2). All patients received midazolam 7.5 mg po and 3 minutes preoxygenation with 100% O2 prior to the induction of anaesthesia. Anaesthesia was induced with IV fentanyl 2 mcg/kg, propofol 2 mg/kg and paralyzed with IV rocuronium 0.6-0.8 mg/kg. All patients were maintained with FiO2 of 0.35, sevoflurane with MAC of 1.0-1.2 and end CO2 of 30-35 mmHg. Result: The peritoneal insufflations pressures were documented. A series of blood gases were taken prior to preoxygenation, at 30, 60 and 90 minutes post intubation. There was no overall difference between the two groups in terms of the PF ratio (p = 0.142), over time (p = 0.515) and time interaction within groups (p = 0.806) despite lower overall PF ratio in Group 2. Conclusion: There was no significant difference in the partial pressure of oxygen to the fractional inspired oxygen ratio (PF Ratio) in healthy patients ventilated with oxygen-Air or oxygen-nitrous oxide mixtures during laparoscopic cholecyctectomy.

AB - Objective: This randomized single-blind study was designed to evaluate the effects of oxygen administration in air versus in N2O to the PaO 2 / FiO2 (PF ratio) in healthy patients undergoing laparoscopic cholecystectomy. Method: Sixteen patients with ASA I and II, age of less than 65 years and BMI of less than 40 were randomly recruited into two groups to receive either O2 in air gas mixture (Group 1) or O 2 in N2O gas mixture (Group 2). All patients received midazolam 7.5 mg po and 3 minutes preoxygenation with 100% O2 prior to the induction of anaesthesia. Anaesthesia was induced with IV fentanyl 2 mcg/kg, propofol 2 mg/kg and paralyzed with IV rocuronium 0.6-0.8 mg/kg. All patients were maintained with FiO2 of 0.35, sevoflurane with MAC of 1.0-1.2 and end CO2 of 30-35 mmHg. Result: The peritoneal insufflations pressures were documented. A series of blood gases were taken prior to preoxygenation, at 30, 60 and 90 minutes post intubation. There was no overall difference between the two groups in terms of the PF ratio (p = 0.142), over time (p = 0.515) and time interaction within groups (p = 0.806) despite lower overall PF ratio in Group 2. Conclusion: There was no significant difference in the partial pressure of oxygen to the fractional inspired oxygen ratio (PF Ratio) in healthy patients ventilated with oxygen-Air or oxygen-nitrous oxide mixtures during laparoscopic cholecyctectomy.

KW - Fractional inspired

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