Oxidative stress resistance and fitness-compensatory response in vancomycin-intermediate Staphylococcus aureus (VISA)

Xin Ee Tan, Hui Min Neoh, Longzhu Cui, Keiichi Hiramatsu, A. Rahman A. Jamal

Research output: Contribution to journalComment/debate

Abstract

In this study, vancomycin-intermediate Staphylococcus aureus (VISA) cells carrying vraS and (or) graR mutations were shown to be more resistant to oxidative stress. Caenorhabditis elegans infected with these strains in turn demonstrated lower survival. Altered regulation in oxidative stress response and virulence appear to be physiological adaptations associated with the VISA phenotype in the Mu50 lineage.

Original languageEnglish
Pages (from-to)623-628
Number of pages6
JournalCanadian Journal of Microbiology
Volume65
Issue number8
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Vancomycin
Staphylococcus aureus
Oxidative Stress
Physiological Adaptation
Caenorhabditis elegans
Virulence
Phenotype
Mutation

Keywords

  • Fitness cost
  • Oxidative stress
  • Vancomycin-intermediate Staphylococcus aureus
  • Virulence

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Genetics

Cite this

Oxidative stress resistance and fitness-compensatory response in vancomycin-intermediate Staphylococcus aureus (VISA). / Tan, Xin Ee; Neoh, Hui Min; Cui, Longzhu; Hiramatsu, Keiichi; A. Jamal, A. Rahman.

In: Canadian Journal of Microbiology, Vol. 65, No. 8, 01.01.2019, p. 623-628.

Research output: Contribution to journalComment/debate

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