Oxidative status in bipolar disorder (BD) and its correlation with age, gender and body mass index (BMI)

Jaclyn Tan Ai Chin, Geetha Gunasekaran, Mohd Hanafi Ahmad Damanhuri, Chan Lai Fong, Loo Jiann Lin, Goon Jo Aan

Research output: Contribution to journalArticle

Abstract

Bipolar disorder (BD) is a chronic psychiatric illness which molecular foundations have yet to be elucidated. Oxidative stress appears to be a promising field of study to understand the formation of this disease in molecular level. The objective was to investigate the oxidative status of BD and its association with age, gender and body mass index (BMI). A cross-sectional study was conducted in a tertiary university hospital in Cheras, Malaysia on 55 patients with BD diagnosed using Mini Neuropsychiatric Interview (MINI). Peripheral markers of oxidative stress which include superoxide dismutase (SOD), glutathione peroxidise (GPx), catalase (CAT), malondialdehyde (MDA) and DNA damage were examined in subjects with BD (n=55) and compared to healthy controls (n=28). BD patients had significantly higher concentrations of MDA compared to healthy controls (p<0.001). Concentration of MDA was significantly higher in BD patients aged 40 and above compared to those aged 39 years and below (p<0.05). The concentration of MDA did not show significant difference between male and female BD patients, likewise between patients with BMI below and above 25. The percentage of normal DNA in healthy controls was significantly higher than that of BD patients (p<0.001), while percentage of mildly and severely damaged DNA in BD patients was significantly higher than that of healthy controls (mildly damaged: p<0.001; severely damaged: p<0.001). The severity of DNA damage in the BD patients was similar when compared between age, gender and BMI. SOD activity of BD patients was found to be comparable to that of healthy subjects as well as when compared between gender and age, but was significantly lower in subjects with BMI above 25 (p<0.05). CAT activity was significantly higher in BD patients compared to controls (p<0.001), while no significant difference was found when compared between gender, age and BMI. GPx activity did not show significant difference when compared between BD and healthy controls, gender, age and BMI. Multiple linear regression analysis showed that the percentage of normal DNA increases with age in BD patients (p<0.001), while the percentage of damaged DNA decreases with age (mildly damaged: p<0.002; severely damaged: p<0.001). Percentage of normal and damaged DNA are not significantly correlated with BMI, while all antioxidative enzymes (SOD, GPx, CAT) and MDA concentration did not show significant correlation with age and BMI. In conclusion, age and BMI are associated with the oxidative status of BD patients regardless of gender.

Original languageEnglish
Pages (from-to)1083-1095
Number of pages13
JournalSains Malaysiana
Volume48
Issue number5
DOIs
Publication statusPublished - 1 Jan 2019

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Bipolar Disorder
Body Mass Index
Malondialdehyde
Catalase
DNA
Superoxide Dismutase
Glutathione
DNA Damage
Oxidative Stress
Malaysia
Tertiary Care Centers
Psychiatry
Linear Models
Healthy Volunteers
Chronic Disease
Cross-Sectional Studies

Keywords

  • Bipolar disorder
  • Catalase
  • Glutathione peroxidase
  • Malondialdehyde
  • Superoxide dismutase

ASJC Scopus subject areas

  • General

Cite this

Oxidative status in bipolar disorder (BD) and its correlation with age, gender and body mass index (BMI). / Ai Chin, Jaclyn Tan; Gunasekaran, Geetha; Ahmad Damanhuri, Mohd Hanafi; Fong, Chan Lai; Lin, Loo Jiann; Jo Aan, Goon.

In: Sains Malaysiana, Vol. 48, No. 5, 01.01.2019, p. 1083-1095.

Research output: Contribution to journalArticle

Ai Chin, Jaclyn Tan ; Gunasekaran, Geetha ; Ahmad Damanhuri, Mohd Hanafi ; Fong, Chan Lai ; Lin, Loo Jiann ; Jo Aan, Goon. / Oxidative status in bipolar disorder (BD) and its correlation with age, gender and body mass index (BMI). In: Sains Malaysiana. 2019 ; Vol. 48, No. 5. pp. 1083-1095.
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