Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens

Jean Duplex Wansi, Osman Mesaik Mohammed Ahmed Hassan, David Dako Chiozem, Krishna Prasad Devkota, Nicolas Gaboriaud-Kolar, Marie Christine Lallemand, Jean Wandji, M. Iqbal Choudhary, Norbert Sewald

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Two new β-indoloquinazoline alkaloids, orisuaveoline A (1) and orisuaveoline B (2), two new furoquinoline alkaloids, quinosuaveoline A (5) and quinosuaveoline B (6), and 12 known compounds were isolated from Oricia suaveolens. The structures of the new compounds were deduced by spectroscopic studies. The absolute configuration of nkolbisine (4) was also determined. Compounds 2, 3, 6-8, 10, and 14 were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against A549 lung carcinoma cells.

Original languageEnglish
Pages (from-to)1942-1945
Number of pages4
JournalJournal of Natural Products
Volume71
Issue number11
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

Fingerprint

Respiratory Burst
Alkaloids
Cytotoxicity
Assays
Cells
Carcinoma
Lung
indoloquinazoline
orisuaveoline A
orisuaveoline B
quinosuaveoline A
quinosuaveoline B

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Wansi, J. D., Mohammed Ahmed Hassan, O. M., Chiozem, D. D., Devkota, K. P., Gaboriaud-Kolar, N., Lallemand, M. C., ... Sewald, N. (2008). Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens. Journal of Natural Products, 71(11), 1942-1945. https://doi.org/10.1021/np800276f

Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens. / Wansi, Jean Duplex; Mohammed Ahmed Hassan, Osman Mesaik; Chiozem, David Dako; Devkota, Krishna Prasad; Gaboriaud-Kolar, Nicolas; Lallemand, Marie Christine; Wandji, Jean; Choudhary, M. Iqbal; Sewald, Norbert.

In: Journal of Natural Products, Vol. 71, No. 11, 11.2008, p. 1942-1945.

Research output: Contribution to journalArticle

Wansi, JD, Mohammed Ahmed Hassan, OM, Chiozem, DD, Devkota, KP, Gaboriaud-Kolar, N, Lallemand, MC, Wandji, J, Choudhary, MI & Sewald, N 2008, 'Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens', Journal of Natural Products, vol. 71, no. 11, pp. 1942-1945. https://doi.org/10.1021/np800276f
Wansi JD, Mohammed Ahmed Hassan OM, Chiozem DD, Devkota KP, Gaboriaud-Kolar N, Lallemand MC et al. Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens. Journal of Natural Products. 2008 Nov;71(11):1942-1945. https://doi.org/10.1021/np800276f
Wansi, Jean Duplex ; Mohammed Ahmed Hassan, Osman Mesaik ; Chiozem, David Dako ; Devkota, Krishna Prasad ; Gaboriaud-Kolar, Nicolas ; Lallemand, Marie Christine ; Wandji, Jean ; Choudhary, M. Iqbal ; Sewald, Norbert. / Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens. In: Journal of Natural Products. 2008 ; Vol. 71, No. 11. pp. 1942-1945.
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