Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)

Luc Meva a Mbaze, Jean Alexandre Lado, Jean Duplex Wansi, Tze Chieh Shiao, David Dako Chiozem, Osman Mesaik Mohammed Ahmed Hassan, Muhammad Iqbal Choudhary, Marie Aleth Lacaille-Dubois, Jean Wandji, René Roy, Norbert Sewald

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Two amides, heitziamide A and heitziamide B and two phenylethanoids, heitziethanoid A and heitziethanoid B together with thirteen known compounds were isolated from F. heitzii (Letouzey). The structures of all compounds were established by spectroscopic analysis. Nine compounds were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against PC-3 prostate cancer cells. All compounds exhibited a clear suppressive effect on phagocytosis response upon activation with serum opsonized zymosan at the range of IC50 = 2.0-6.5 μM, but no cytotoxic effect was observed (IC50 > 100 μM).

Original languageEnglish
Pages (from-to)1442-1447
Number of pages6
JournalPhytochemistry
Volume70
Issue number11-12
DOIs
Publication statusPublished - Jul 2009
Externally publishedYes

Fingerprint

Zanthoxylum
Rutaceae
Lignans
Zymosan
Spectroscopic analysis
Respiratory Burst
lignans
Cytotoxicity
amides
Amides
Inhibitory Concentration 50
inhibitory concentration 50
cytotoxicity
Assays
bark
Chemical activation
Cells
zymosan
stems
prostatic neoplasms

Keywords

  • Amides
  • Cytotoxicity
  • Fagara heitzii
  • Lignans
  • Oxidative burst inhibition
  • Phenylethanoids

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Horticulture

Cite this

Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). / Mbaze, Luc Meva a; Lado, Jean Alexandre; Wansi, Jean Duplex; Shiao, Tze Chieh; Chiozem, David Dako; Mohammed Ahmed Hassan, Osman Mesaik; Choudhary, Muhammad Iqbal; Lacaille-Dubois, Marie Aleth; Wandji, Jean; Roy, René; Sewald, Norbert.

In: Phytochemistry, Vol. 70, No. 11-12, 07.2009, p. 1442-1447.

Research output: Contribution to journalArticle

Mbaze, LMA, Lado, JA, Wansi, JD, Shiao, TC, Chiozem, DD, Mohammed Ahmed Hassan, OM, Choudhary, MI, Lacaille-Dubois, MA, Wandji, J, Roy, R & Sewald, N 2009, 'Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)', Phytochemistry, vol. 70, no. 11-12, pp. 1442-1447. https://doi.org/10.1016/j.phytochem.2009.08.007
Mbaze, Luc Meva a ; Lado, Jean Alexandre ; Wansi, Jean Duplex ; Shiao, Tze Chieh ; Chiozem, David Dako ; Mohammed Ahmed Hassan, Osman Mesaik ; Choudhary, Muhammad Iqbal ; Lacaille-Dubois, Marie Aleth ; Wandji, Jean ; Roy, René ; Sewald, Norbert. / Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). In: Phytochemistry. 2009 ; Vol. 70, No. 11-12. pp. 1442-1447.
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