Overview of Urethral Reconstruction by Tissue Engineering: Current Strategies, Clinical Status and Future Direction

Zahra Rashidbenam, Mohd Hafidzul Jasman, Pezhman Hafez, Guan Hee Tan, Eng Hong Goh, Xeng Inn Fam, Christopher Chee Kong Ho, Zulkifli Md Zainuddin, Reynu Rajan, Fatimah Mohd Nor, Mohamad Aznan Shuhaili, Nik Ritza Kosai, Farrah Hani Imran, Min Hwei Ng

Research output: Contribution to journalReview article

Abstract

BACKGROUND:: Urinary tract is subjected to a variety of disorders such as urethral stricture, which often develops as a result of scarring process. Urethral stricture can be treated by urethral dilation and urethrotomy; but in cases of long urethral strictures, substitution urethroplasty with genital skin and buccal mucosa grafts is the only option. However a number of complications such as infection as a result of hair growth in neo-urethra, and stone formation restrict the application of those grafts. Therefore, tissue engineering techniques recently emerged as an alternative approach, aiming to overcome those restrictions. The aim of this review is to provide a comprehensive coverage on the strategies employed and the translational status of urethral tissue engineering over the past years and to propose a combinatory strategy for the future of urethral tissue engineering. METHODs:: Data collection was based on the key articles published in English language in years between 2006 and 2018 using the searching terms of urethral stricture and tissue engineering on PubMed database. RESULTS:: Differentiation of mesenchymal stem cells into urothelial and smooth muscle cells to be used for urologic application does not offer any advantage over autologous urothelial and smooth muscle cells. Among studied scaffolds, synthetic scaffolds with proper porosity and mechanical strength is the best option to be used for urethral tissue engineering. CONCLUSION:: Hypoxia-preconditioned mesenchymal stem cells in combination with autologous cells seeded on a pre-vascularized synthetic and biodegradable scaffold can be said to be the best combinatory strategy in engineering of human urethra.

Original languageEnglish
Pages (from-to)365-384
Number of pages20
JournalTissue Engineering and Regenerative Medicine
Volume16
Issue number4
DOIs
Publication statusPublished - 14 Aug 2019

Fingerprint

Tissue Engineering
Urethral Stricture
Tissue engineering
Scaffolds
Urethra
Stem cells
Mesenchymal Stromal Cells
Grafts
Smooth Muscle Myocytes
Muscle
Cells
Transplants
Human Engineering
Porosity
Mouth Mucosa
Urinary Tract
PubMed
Hair
Strength of materials
Cicatrix

Keywords

  • Scaffold
  • Tissue engineering
  • Urethral reconstruction
  • Urethral stricture

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Overview of Urethral Reconstruction by Tissue Engineering : Current Strategies, Clinical Status and Future Direction. / Rashidbenam, Zahra; Jasman, Mohd Hafidzul; Hafez, Pezhman; Tan, Guan Hee; Goh, Eng Hong; Fam, Xeng Inn; Ho, Christopher Chee Kong; Zainuddin, Zulkifli Md; Rajan, Reynu; Nor, Fatimah Mohd; Shuhaili, Mohamad Aznan; Kosai, Nik Ritza; Imran, Farrah Hani; Ng, Min Hwei.

In: Tissue Engineering and Regenerative Medicine, Vol. 16, No. 4, 14.08.2019, p. 365-384.

Research output: Contribution to journalReview article

Rashidbenam, Zahra ; Jasman, Mohd Hafidzul ; Hafez, Pezhman ; Tan, Guan Hee ; Goh, Eng Hong ; Fam, Xeng Inn ; Ho, Christopher Chee Kong ; Zainuddin, Zulkifli Md ; Rajan, Reynu ; Nor, Fatimah Mohd ; Shuhaili, Mohamad Aznan ; Kosai, Nik Ritza ; Imran, Farrah Hani ; Ng, Min Hwei. / Overview of Urethral Reconstruction by Tissue Engineering : Current Strategies, Clinical Status and Future Direction. In: Tissue Engineering and Regenerative Medicine. 2019 ; Vol. 16, No. 4. pp. 365-384.
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abstract = "BACKGROUND:: Urinary tract is subjected to a variety of disorders such as urethral stricture, which often develops as a result of scarring process. Urethral stricture can be treated by urethral dilation and urethrotomy; but in cases of long urethral strictures, substitution urethroplasty with genital skin and buccal mucosa grafts is the only option. However a number of complications such as infection as a result of hair growth in neo-urethra, and stone formation restrict the application of those grafts. Therefore, tissue engineering techniques recently emerged as an alternative approach, aiming to overcome those restrictions. The aim of this review is to provide a comprehensive coverage on the strategies employed and the translational status of urethral tissue engineering over the past years and to propose a combinatory strategy for the future of urethral tissue engineering. METHODs:: Data collection was based on the key articles published in English language in years between 2006 and 2018 using the searching terms of urethral stricture and tissue engineering on PubMed database. RESULTS:: Differentiation of mesenchymal stem cells into urothelial and smooth muscle cells to be used for urologic application does not offer any advantage over autologous urothelial and smooth muscle cells. Among studied scaffolds, synthetic scaffolds with proper porosity and mechanical strength is the best option to be used for urethral tissue engineering. CONCLUSION:: Hypoxia-preconditioned mesenchymal stem cells in combination with autologous cells seeded on a pre-vascularized synthetic and biodegradable scaffold can be said to be the best combinatory strategy in engineering of human urethra.",
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AU - Goh, Eng Hong

AU - Fam, Xeng Inn

AU - Ho, Christopher Chee Kong

AU - Zainuddin, Zulkifli Md

AU - Rajan, Reynu

AU - Nor, Fatimah Mohd

AU - Shuhaili, Mohamad Aznan

AU - Kosai, Nik Ritza

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N2 - BACKGROUND:: Urinary tract is subjected to a variety of disorders such as urethral stricture, which often develops as a result of scarring process. Urethral stricture can be treated by urethral dilation and urethrotomy; but in cases of long urethral strictures, substitution urethroplasty with genital skin and buccal mucosa grafts is the only option. However a number of complications such as infection as a result of hair growth in neo-urethra, and stone formation restrict the application of those grafts. Therefore, tissue engineering techniques recently emerged as an alternative approach, aiming to overcome those restrictions. The aim of this review is to provide a comprehensive coverage on the strategies employed and the translational status of urethral tissue engineering over the past years and to propose a combinatory strategy for the future of urethral tissue engineering. METHODs:: Data collection was based on the key articles published in English language in years between 2006 and 2018 using the searching terms of urethral stricture and tissue engineering on PubMed database. RESULTS:: Differentiation of mesenchymal stem cells into urothelial and smooth muscle cells to be used for urologic application does not offer any advantage over autologous urothelial and smooth muscle cells. Among studied scaffolds, synthetic scaffolds with proper porosity and mechanical strength is the best option to be used for urethral tissue engineering. CONCLUSION:: Hypoxia-preconditioned mesenchymal stem cells in combination with autologous cells seeded on a pre-vascularized synthetic and biodegradable scaffold can be said to be the best combinatory strategy in engineering of human urethra.

AB - BACKGROUND:: Urinary tract is subjected to a variety of disorders such as urethral stricture, which often develops as a result of scarring process. Urethral stricture can be treated by urethral dilation and urethrotomy; but in cases of long urethral strictures, substitution urethroplasty with genital skin and buccal mucosa grafts is the only option. However a number of complications such as infection as a result of hair growth in neo-urethra, and stone formation restrict the application of those grafts. Therefore, tissue engineering techniques recently emerged as an alternative approach, aiming to overcome those restrictions. The aim of this review is to provide a comprehensive coverage on the strategies employed and the translational status of urethral tissue engineering over the past years and to propose a combinatory strategy for the future of urethral tissue engineering. METHODs:: Data collection was based on the key articles published in English language in years between 2006 and 2018 using the searching terms of urethral stricture and tissue engineering on PubMed database. RESULTS:: Differentiation of mesenchymal stem cells into urothelial and smooth muscle cells to be used for urologic application does not offer any advantage over autologous urothelial and smooth muscle cells. Among studied scaffolds, synthetic scaffolds with proper porosity and mechanical strength is the best option to be used for urethral tissue engineering. CONCLUSION:: Hypoxia-preconditioned mesenchymal stem cells in combination with autologous cells seeded on a pre-vascularized synthetic and biodegradable scaffold can be said to be the best combinatory strategy in engineering of human urethra.

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