Overview of the role of B2-adrenergic receptor variants in human hypertension

Ahmed Atia, Azman Abdullah, Nadia Alrawaiq

Research output: Contribution to journalArticle

Abstract

Essential hypertension isa complex traitto whichmultifactorial origin arising from an interaction between genetic and environmental factorscontribute interactively. Consequently, the identification of genes related to hypertension is complicated by the heterogeneity of its causes and the possibility that various genes with moderate impacts, probably acting in a same manner, affect blood pressure and the occurrence of hypertension. Multiple studies have suggested that variation within the β2-adrenergic receptor (ADRB2) is implicated in blood pressure regulation and the development of hypertension. The evidence for ADRB2 gene association with hypertension is not conclusive. There are conflicting reports on the association of these polymorphisms with hypertension. Several reports have suggested the association of the ADRB2 variants with the prevalence of hypertension and systolic blood pressure (BP)whilst others refuted the association. The role of these findings is reviewed here, and their potential clinical influences in human hypertension.

Original languageEnglish
Pages (from-to)1611-1615
Number of pages5
JournalInternational Journal of PharmTech Research
Volume6
Issue number5
Publication statusPublished - 1 Sep 2014

Fingerprint

Adrenergic Receptors
Hypertension
Blood Pressure
Genes

Keywords

  • ADRB2
  • Hypertension
  • Polymorphism
  • SNPs

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Overview of the role of B2-adrenergic receptor variants in human hypertension. / Atia, Ahmed; Abdullah, Azman; Alrawaiq, Nadia.

In: International Journal of PharmTech Research, Vol. 6, No. 5, 01.09.2014, p. 1611-1615.

Research output: Contribution to journalArticle

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