Abstract
Gestational trophoblastic disease (GTD) is a common problem among Asian ethnics. A total of 102 women with molar pregnancies between 1 January 2005 and 31 December 2010, were analysed. The aim of the study was to determine the outcome of all molar pregnancies in our institution. The local incidence of molar pregnancy was 2.6 per 1,000 deliveries. A total of 48 women (47.1%) had complete hydatidiform mole and another 54 (52.9%) had partial mole. The mean age of the women with molar pregnancies was 32.0 ± 7.9 years. The mean gestational age at initial diagnosis was 11 weeks ± 3 days. The majority (97 women, 95.1%) had symptoms of vaginal bleeding and 18 (17.6%) women had a uterus larger than dates. A total of 48 (47.1%) women had ultrasound scan findings of 'snow-storm' appearance. None of the women with uncomplicated molar pregnancy had evidence of relapse following one undetectable serum β-hCG level. Four out of the 102 women (3.9%) developed persistent trophoblastic disease before attaining one undetectable serum β-hCG level. All four women required single agent methotrexate and they remained in remission. The prognosis for uncomplicated molar pregnancy is good. Establishment of a National Trophoblastic Centre is recommended to maintain optimal outcome.
| Original language | English |
|---|---|
| Pages (from-to) | 191-193 |
| Number of pages | 3 |
| Journal | Journal of Obstetrics and Gynaecology |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2013 |
Fingerprint
Keywords
- β-hCG
- Complete hydatidiform mole
- Molar pregnancy
- Partial
- Surveillance
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Outcome of molar pregnancies in Malaysia : A tertiary centre experience. / Kampan, Nirmala @ Chandralega; Mohamed Ismail, Nor Azlin; Harry, S. R.; Lim, Pei Shan; Shafiee, Mohamad Nasir; Abdul Ghani, Nur Azurah; Omar, Mohd Hashim; Hatta, M. D.
In: Journal of Obstetrics and Gynaecology, Vol. 33, No. 2, 02.2013, p. 191-193.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Outcome of molar pregnancies in Malaysia
T2 - A tertiary centre experience
AU - Kampan, Nirmala @ Chandralega
AU - Mohamed Ismail, Nor Azlin
AU - Harry, S. R.
AU - Lim, Pei Shan
AU - Shafiee, Mohamad Nasir
AU - Abdul Ghani, Nur Azurah
AU - Omar, Mohd Hashim
AU - Hatta, M. D.
PY - 2013/2
Y1 - 2013/2
N2 - Gestational trophoblastic disease (GTD) is a common problem among Asian ethnics. A total of 102 women with molar pregnancies between 1 January 2005 and 31 December 2010, were analysed. The aim of the study was to determine the outcome of all molar pregnancies in our institution. The local incidence of molar pregnancy was 2.6 per 1,000 deliveries. A total of 48 women (47.1%) had complete hydatidiform mole and another 54 (52.9%) had partial mole. The mean age of the women with molar pregnancies was 32.0 ± 7.9 years. The mean gestational age at initial diagnosis was 11 weeks ± 3 days. The majority (97 women, 95.1%) had symptoms of vaginal bleeding and 18 (17.6%) women had a uterus larger than dates. A total of 48 (47.1%) women had ultrasound scan findings of 'snow-storm' appearance. None of the women with uncomplicated molar pregnancy had evidence of relapse following one undetectable serum β-hCG level. Four out of the 102 women (3.9%) developed persistent trophoblastic disease before attaining one undetectable serum β-hCG level. All four women required single agent methotrexate and they remained in remission. The prognosis for uncomplicated molar pregnancy is good. Establishment of a National Trophoblastic Centre is recommended to maintain optimal outcome.
AB - Gestational trophoblastic disease (GTD) is a common problem among Asian ethnics. A total of 102 women with molar pregnancies between 1 January 2005 and 31 December 2010, were analysed. The aim of the study was to determine the outcome of all molar pregnancies in our institution. The local incidence of molar pregnancy was 2.6 per 1,000 deliveries. A total of 48 women (47.1%) had complete hydatidiform mole and another 54 (52.9%) had partial mole. The mean age of the women with molar pregnancies was 32.0 ± 7.9 years. The mean gestational age at initial diagnosis was 11 weeks ± 3 days. The majority (97 women, 95.1%) had symptoms of vaginal bleeding and 18 (17.6%) women had a uterus larger than dates. A total of 48 (47.1%) women had ultrasound scan findings of 'snow-storm' appearance. None of the women with uncomplicated molar pregnancy had evidence of relapse following one undetectable serum β-hCG level. Four out of the 102 women (3.9%) developed persistent trophoblastic disease before attaining one undetectable serum β-hCG level. All four women required single agent methotrexate and they remained in remission. The prognosis for uncomplicated molar pregnancy is good. Establishment of a National Trophoblastic Centre is recommended to maintain optimal outcome.
KW - β-hCG
KW - Complete hydatidiform mole
KW - Molar pregnancy
KW - Partial
KW - Surveillance
UR - http://www.scopus.com/inward/record.url?scp=84874432043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874432043&partnerID=8YFLogxK
U2 - 10.3109/01443615.2012.741150
DO - 10.3109/01443615.2012.741150
M3 - Article
C2 - 23445147
AN - SCOPUS:84874432043
VL - 33
SP - 191
EP - 193
JO - Asia-Oceania Journal of Obstetrics and Gynaecology
JF - Asia-Oceania Journal of Obstetrics and Gynaecology
SN - 1341-8076
IS - 2
ER -