Outcome of molar pregnancies in Malaysia: A tertiary centre experience

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5 Citations (Scopus)

Abstract

Gestational trophoblastic disease (GTD) is a common problem among Asian ethnics. A total of 102 women with molar pregnancies between 1 January 2005 and 31 December 2010, were analysed. The aim of the study was to determine the outcome of all molar pregnancies in our institution. The local incidence of molar pregnancy was 2.6 per 1,000 deliveries. A total of 48 women (47.1%) had complete hydatidiform mole and another 54 (52.9%) had partial mole. The mean age of the women with molar pregnancies was 32.0 ± 7.9 years. The mean gestational age at initial diagnosis was 11 weeks ± 3 days. The majority (97 women, 95.1%) had symptoms of vaginal bleeding and 18 (17.6%) women had a uterus larger than dates. A total of 48 (47.1%) women had ultrasound scan findings of 'snow-storm' appearance. None of the women with uncomplicated molar pregnancy had evidence of relapse following one undetectable serum β-hCG level. Four out of the 102 women (3.9%) developed persistent trophoblastic disease before attaining one undetectable serum β-hCG level. All four women required single agent methotrexate and they remained in remission. The prognosis for uncomplicated molar pregnancy is good. Establishment of a National Trophoblastic Centre is recommended to maintain optimal outcome.

Original languageEnglish
Pages (from-to)191-193
Number of pages3
JournalJournal of Obstetrics and Gynaecology
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Hydatidiform Mole
Malaysia
Gestational Trophoblastic Disease
Snow
Uterine Hemorrhage
Serum
Methotrexate
Gestational Age
Uterus
Recurrence

Keywords

  • β-hCG
  • Complete hydatidiform mole
  • Molar pregnancy
  • Partial
  • Surveillance

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

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title = "Outcome of molar pregnancies in Malaysia: A tertiary centre experience",
abstract = "Gestational trophoblastic disease (GTD) is a common problem among Asian ethnics. A total of 102 women with molar pregnancies between 1 January 2005 and 31 December 2010, were analysed. The aim of the study was to determine the outcome of all molar pregnancies in our institution. The local incidence of molar pregnancy was 2.6 per 1,000 deliveries. A total of 48 women (47.1{\%}) had complete hydatidiform mole and another 54 (52.9{\%}) had partial mole. The mean age of the women with molar pregnancies was 32.0 ± 7.9 years. The mean gestational age at initial diagnosis was 11 weeks ± 3 days. The majority (97 women, 95.1{\%}) had symptoms of vaginal bleeding and 18 (17.6{\%}) women had a uterus larger than dates. A total of 48 (47.1{\%}) women had ultrasound scan findings of 'snow-storm' appearance. None of the women with uncomplicated molar pregnancy had evidence of relapse following one undetectable serum β-hCG level. Four out of the 102 women (3.9{\%}) developed persistent trophoblastic disease before attaining one undetectable serum β-hCG level. All four women required single agent methotrexate and they remained in remission. The prognosis for uncomplicated molar pregnancy is good. Establishment of a National Trophoblastic Centre is recommended to maintain optimal outcome.",
keywords = "β-hCG, Complete hydatidiform mole, Molar pregnancy, Partial, Surveillance",
author = "Kampan, {Nirmala @ Chandralega} and {Mohamed Ismail}, {Nor Azlin} and Harry, {S. R.} and Lim, {Pei Shan} and Shafiee, {Mohamad Nasir} and {Abdul Ghani}, {Nur Azurah} and Omar, {Mohd Hashim} and Hatta, {M. D.}",
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AU - Shafiee, Mohamad Nasir

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AU - Omar, Mohd Hashim

AU - Hatta, M. D.

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AB - Gestational trophoblastic disease (GTD) is a common problem among Asian ethnics. A total of 102 women with molar pregnancies between 1 January 2005 and 31 December 2010, were analysed. The aim of the study was to determine the outcome of all molar pregnancies in our institution. The local incidence of molar pregnancy was 2.6 per 1,000 deliveries. A total of 48 women (47.1%) had complete hydatidiform mole and another 54 (52.9%) had partial mole. The mean age of the women with molar pregnancies was 32.0 ± 7.9 years. The mean gestational age at initial diagnosis was 11 weeks ± 3 days. The majority (97 women, 95.1%) had symptoms of vaginal bleeding and 18 (17.6%) women had a uterus larger than dates. A total of 48 (47.1%) women had ultrasound scan findings of 'snow-storm' appearance. None of the women with uncomplicated molar pregnancy had evidence of relapse following one undetectable serum β-hCG level. Four out of the 102 women (3.9%) developed persistent trophoblastic disease before attaining one undetectable serum β-hCG level. All four women required single agent methotrexate and they remained in remission. The prognosis for uncomplicated molar pregnancy is good. Establishment of a National Trophoblastic Centre is recommended to maintain optimal outcome.

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