Osteoporosis: Possible pathways involved and the role of natural phytoestrogens in bone metabolism

Zar Chi Thent, Srijit Das, Pasuk Mahakkanukrauh, Virginia Lanzotti

Research output: Contribution to journalArticle

Abstract

The incidence of post-menopausal osteoporosis is increasing globally. In post-menopausal osteoporosis, there is deficiency in oestrogen level resulting in bone loss and fractures. Bone formation is under the control of different hormones. In the present review, we highlight few pathways such as RANKL/RANK, apoptosis and Wnt/β-catenin signalling pathways and phytoestrogens involved in the bone metabolism. RANKL/RANK signalling is responsible for regulating the formation and activation of multinucleated osteoclasts from their precursors which is responsible for the survival of normal bone remodelling. Apoptosis regulates the development, growth and maintains the bone tissues. The Wnt pathway is an important pharmacological target for bone anabolic drugs and its future discovery. In today's world, herbal remedies are used to treat post-menopausal osteoporosis as these products contain phytoestrogens. These phytoestrogens are oestrogen like compounds which influence bone metabolism. The phytoestrogens provide better therapeutic effect in reducing the RANKL, osteoclastogenesis, inflammatory markers, and increase the osteogenic markers in the bone cells or osteoblasts. We discuss the mechanism of action of few phytoestrogens such as genistein, daidzein and equol which are beneficial for improvement of the bone health. Daidzein enhances osteoblast growth via the upregulation of BMP expression in primary osteoblast cells and it is a potential antiosteoporotic agent. Genistein also possesses antioestrogenic property by virtue of its competitive binding to the same receptors as oestradiol. Equol regulates the bone loss via hemopoiesis and inflammatory cytokine production. Thus, phytoestrogens could be efficiently used as osteoprotective agents for the treatment of individuals with post-menopausal osteoporosis.

Original languageEnglish
Pages (from-to)2007-2019
Number of pages13
JournalSains Malaysiana
Volume48
Issue number9
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Phytoestrogens
Osteoporosis
Postmenopausal Osteoporosis
Bone and Bones
Equol
Osteoblasts
Wnt Signaling Pathway
Genistein
Osteogenesis
Estrogens
Apoptosis
Estradiol Receptors
Catenins
Competitive Binding
Bone Remodeling
Bone Fractures
Therapeutic Uses
Osteoclasts
Growth and Development
Up-Regulation

Keywords

  • Fracture
  • Oestrogen
  • Pharmacology
  • Post-menopausal
  • Treatment

ASJC Scopus subject areas

  • General

Cite this

Osteoporosis : Possible pathways involved and the role of natural phytoestrogens in bone metabolism. / Thent, Zar Chi; Das, Srijit; Mahakkanukrauh, Pasuk; Lanzotti, Virginia.

In: Sains Malaysiana, Vol. 48, No. 9, 01.01.2019, p. 2007-2019.

Research output: Contribution to journalArticle

Thent, Zar Chi ; Das, Srijit ; Mahakkanukrauh, Pasuk ; Lanzotti, Virginia. / Osteoporosis : Possible pathways involved and the role of natural phytoestrogens in bone metabolism. In: Sains Malaysiana. 2019 ; Vol. 48, No. 9. pp. 2007-2019.
@article{903d9438ebb946c3b39dc465adca2bab,
title = "Osteoporosis: Possible pathways involved and the role of natural phytoestrogens in bone metabolism",
abstract = "The incidence of post-menopausal osteoporosis is increasing globally. In post-menopausal osteoporosis, there is deficiency in oestrogen level resulting in bone loss and fractures. Bone formation is under the control of different hormones. In the present review, we highlight few pathways such as RANKL/RANK, apoptosis and Wnt/β-catenin signalling pathways and phytoestrogens involved in the bone metabolism. RANKL/RANK signalling is responsible for regulating the formation and activation of multinucleated osteoclasts from their precursors which is responsible for the survival of normal bone remodelling. Apoptosis regulates the development, growth and maintains the bone tissues. The Wnt pathway is an important pharmacological target for bone anabolic drugs and its future discovery. In today's world, herbal remedies are used to treat post-menopausal osteoporosis as these products contain phytoestrogens. These phytoestrogens are oestrogen like compounds which influence bone metabolism. The phytoestrogens provide better therapeutic effect in reducing the RANKL, osteoclastogenesis, inflammatory markers, and increase the osteogenic markers in the bone cells or osteoblasts. We discuss the mechanism of action of few phytoestrogens such as genistein, daidzein and equol which are beneficial for improvement of the bone health. Daidzein enhances osteoblast growth via the upregulation of BMP expression in primary osteoblast cells and it is a potential antiosteoporotic agent. Genistein also possesses antioestrogenic property by virtue of its competitive binding to the same receptors as oestradiol. Equol regulates the bone loss via hemopoiesis and inflammatory cytokine production. Thus, phytoestrogens could be efficiently used as osteoprotective agents for the treatment of individuals with post-menopausal osteoporosis.",
keywords = "Fracture, Oestrogen, Pharmacology, Post-menopausal, Treatment",
author = "Thent, {Zar Chi} and Srijit Das and Pasuk Mahakkanukrauh and Virginia Lanzotti",
year = "2019",
month = "1",
day = "1",
doi = "10.17576/jsm-2019-4809-22",
language = "English",
volume = "48",
pages = "2007--2019",
journal = "Sains Malaysiana",
issn = "0126-6039",
publisher = "Penerbit Universiti Kebangsaan Malaysia",
number = "9",

}

TY - JOUR

T1 - Osteoporosis

T2 - Possible pathways involved and the role of natural phytoestrogens in bone metabolism

AU - Thent, Zar Chi

AU - Das, Srijit

AU - Mahakkanukrauh, Pasuk

AU - Lanzotti, Virginia

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The incidence of post-menopausal osteoporosis is increasing globally. In post-menopausal osteoporosis, there is deficiency in oestrogen level resulting in bone loss and fractures. Bone formation is under the control of different hormones. In the present review, we highlight few pathways such as RANKL/RANK, apoptosis and Wnt/β-catenin signalling pathways and phytoestrogens involved in the bone metabolism. RANKL/RANK signalling is responsible for regulating the formation and activation of multinucleated osteoclasts from their precursors which is responsible for the survival of normal bone remodelling. Apoptosis regulates the development, growth and maintains the bone tissues. The Wnt pathway is an important pharmacological target for bone anabolic drugs and its future discovery. In today's world, herbal remedies are used to treat post-menopausal osteoporosis as these products contain phytoestrogens. These phytoestrogens are oestrogen like compounds which influence bone metabolism. The phytoestrogens provide better therapeutic effect in reducing the RANKL, osteoclastogenesis, inflammatory markers, and increase the osteogenic markers in the bone cells or osteoblasts. We discuss the mechanism of action of few phytoestrogens such as genistein, daidzein and equol which are beneficial for improvement of the bone health. Daidzein enhances osteoblast growth via the upregulation of BMP expression in primary osteoblast cells and it is a potential antiosteoporotic agent. Genistein also possesses antioestrogenic property by virtue of its competitive binding to the same receptors as oestradiol. Equol regulates the bone loss via hemopoiesis and inflammatory cytokine production. Thus, phytoestrogens could be efficiently used as osteoprotective agents for the treatment of individuals with post-menopausal osteoporosis.

AB - The incidence of post-menopausal osteoporosis is increasing globally. In post-menopausal osteoporosis, there is deficiency in oestrogen level resulting in bone loss and fractures. Bone formation is under the control of different hormones. In the present review, we highlight few pathways such as RANKL/RANK, apoptosis and Wnt/β-catenin signalling pathways and phytoestrogens involved in the bone metabolism. RANKL/RANK signalling is responsible for regulating the formation and activation of multinucleated osteoclasts from their precursors which is responsible for the survival of normal bone remodelling. Apoptosis regulates the development, growth and maintains the bone tissues. The Wnt pathway is an important pharmacological target for bone anabolic drugs and its future discovery. In today's world, herbal remedies are used to treat post-menopausal osteoporosis as these products contain phytoestrogens. These phytoestrogens are oestrogen like compounds which influence bone metabolism. The phytoestrogens provide better therapeutic effect in reducing the RANKL, osteoclastogenesis, inflammatory markers, and increase the osteogenic markers in the bone cells or osteoblasts. We discuss the mechanism of action of few phytoestrogens such as genistein, daidzein and equol which are beneficial for improvement of the bone health. Daidzein enhances osteoblast growth via the upregulation of BMP expression in primary osteoblast cells and it is a potential antiosteoporotic agent. Genistein also possesses antioestrogenic property by virtue of its competitive binding to the same receptors as oestradiol. Equol regulates the bone loss via hemopoiesis and inflammatory cytokine production. Thus, phytoestrogens could be efficiently used as osteoprotective agents for the treatment of individuals with post-menopausal osteoporosis.

KW - Fracture

KW - Oestrogen

KW - Pharmacology

KW - Post-menopausal

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=85075442555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075442555&partnerID=8YFLogxK

U2 - 10.17576/jsm-2019-4809-22

DO - 10.17576/jsm-2019-4809-22

M3 - Article

AN - SCOPUS:85075442555

VL - 48

SP - 2007

EP - 2019

JO - Sains Malaysiana

JF - Sains Malaysiana

SN - 0126-6039

IS - 9

ER -