Osteogenic induction of Wharton’s jelly-derived mesenchymal stem cell for bone regeneration

A systematic review

Ayu Suraya Ansari, Muhammad Dain Yazid, Nur Qisya Afifah Veronica Sainik, Rabiatul Adawiyah Razali, Aminuddin Bin Saim, Ruszymah Idrus

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) are emerging as a promising source for bone regeneration in the treatment of bone defects. Previous studies have reported the ability of WJ-MSCs to be induced into the osteogenic lineage. The purpose of this review was to systematically assess the potential of WJ-MSC differentiation into the osteogenic lineage. A comprehensive search was conducted in Medline via Ebscohost and Scopus, where relevant studies published between 1961 and 2018 were selected. The main inclusion criteria were that articles must be primary studies published in English evaluating osteogenic induction of WJ-MSCs. The literature search identified 92 related articles, but only 18 articles met the inclusion criteria. These include two animal studies, three articles containing both in vitro and in vivo assessments, and 13 articles on in vitro studies, all of which are discussed in this review. There were two types of osteogenic induction used in these studies, either chemical or physical. The studies demonstrate that WJ-MSCs are able to differentiate into osteogenic lineage and promote osteogenesis. In light of these observations, it is suggested that WJ-MSCs can be a potential source of stem cells for osteogenic induction, as an alternative to bone marrow-derived mesenchymal stem cells.

Original languageEnglish
Article number2406462
JournalStem Cells International
Volume2018
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Wharton Jelly
Bone Regeneration
Mesenchymal Stromal Cells
Osteogenesis
Cell Differentiation
Stem Cells
Bone Marrow
Bone and Bones

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Osteogenic induction of Wharton’s jelly-derived mesenchymal stem cell for bone regeneration : A systematic review. / Ansari, Ayu Suraya; Yazid, Muhammad Dain; Sainik, Nur Qisya Afifah Veronica; Razali, Rabiatul Adawiyah; Saim, Aminuddin Bin; Idrus, Ruszymah.

In: Stem Cells International, Vol. 2018, 2406462, 01.01.2018.

Research output: Contribution to journalReview article

Ansari, Ayu Suraya ; Yazid, Muhammad Dain ; Sainik, Nur Qisya Afifah Veronica ; Razali, Rabiatul Adawiyah ; Saim, Aminuddin Bin ; Idrus, Ruszymah. / Osteogenic induction of Wharton’s jelly-derived mesenchymal stem cell for bone regeneration : A systematic review. In: Stem Cells International. 2018 ; Vol. 2018.
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