Optimized conditions for pharmaceuticals and personal care products removal by ozonation using response surface methodology

Hind M. Ewadh, Siti Rozaimah Sheikh Abdullah, Hassimi Abu Hasan, Nurina Anwar

Research output: Contribution to journalArticle

Abstract

This study investigated the optimum conditions for the total pharmaceutical and personal care products (PPCPs) removal from PPCPs-contaminated tap water using ozonation treatment. The optimum conditions for maximum PPCPs removal were determined through a Box-Behnken Design (BBD). Three operational variables, i.e. PPCPs concentration (1-600 µg/L, retention time15-30 min and pH 6-9 units) were investigated by setting PPCPs removal concentration as the maximum. The optimum conditions were selected with the highest desirability of 0.967 using the maximum concentration of PPCPs and highest removal of PPCPs from the water (95-100 %) with the minimum retention time for 15 min and the pH was set at pH 8.9. From a validation test of the optimum conditions, it was found that the maximum PPCPs removal from contaminated tap water was closely to the predicted ones with less than 5% error for all the four compounds which give an evidence that ozonation is a good technique to remove PPCPs from water stream.

Original languageEnglish
Pages (from-to)90-99
Number of pages10
JournalInternational Journal of Pharmaceutical Quality Assurance
Volume10
Issue number1
Publication statusPublished - 1 Jan 2019

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Pharmaceutical Services
Water

Keywords

  • 17a-ethinylestradiol
  • Galaxolide
  • Ibuprofen
  • Ketoprofen
  • Optimization
  • Ozonation
  • Pharmaceuticals and personal care products
  • Validation

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cite this

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abstract = "This study investigated the optimum conditions for the total pharmaceutical and personal care products (PPCPs) removal from PPCPs-contaminated tap water using ozonation treatment. The optimum conditions for maximum PPCPs removal were determined through a Box-Behnken Design (BBD). Three operational variables, i.e. PPCPs concentration (1-600 µg/L, retention time15-30 min and pH 6-9 units) were investigated by setting PPCPs removal concentration as the maximum. The optimum conditions were selected with the highest desirability of 0.967 using the maximum concentration of PPCPs and highest removal of PPCPs from the water (95-100 {\%}) with the minimum retention time for 15 min and the pH was set at pH 8.9. From a validation test of the optimum conditions, it was found that the maximum PPCPs removal from contaminated tap water was closely to the predicted ones with less than 5{\%} error for all the four compounds which give an evidence that ozonation is a good technique to remove PPCPs from water stream.",
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