Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design

Asmawati M. Sail, Wan Aida Wan Mustapha, Salma Mohamad Yusop, Mohamad Yusof Maskat, Ahmad Fuad Shamsuddin

Research output: Contribution to journalArticle

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Abstract

Thirteen formulations of cinnamaldehyde/non-ionic surfactant/water system nanoemulsions were prepared using high-pressure homogenisation. The result showed that varying the cinnamaldehyde/surfactant ratio had effect significantly (p<0.05) to mean droplet diameter, polidispersity index, ζ-potential, turbidity and whiteness index, while no significant effect (p>0.05) to viscosity. The mean droplet diameter ranged from 50.48 to 106.4 nm, polydispersity index from 0.06 to 0.28 and ζ-potential from -4.11 to -6.98 mV. The smallest droplet size was produced using 5% cinnamaldehyde and 5% Tween 80. Response surface for droplet diameter showed that the higher the cinnamaldehyde and surfactant concentrations, the larger the droplet diameter, polydispersity index and whiteness index. However, the ζ-potential increased as the cinnamaldehyde concentration decreased and Tween 80 increased. Increasing the cinnamaldehyde concentration led to an increase in turbidity. Formulation of 5% cinnamaldehyde and 6.23% Tween 80 gave no observable separation of the nanoemulsion with minimum droplet size, polidispersity index, viscosity, turbidity, whiteness index and maximum ζ-potential in modulus. The stability of the optimum formulation was sustained for 10 days upon storage at 4°C. The values of droplet diameter, PDI and ζ-potential were 55.50 nm, 0.08 and -5.38 mV, respectively.

Original languageEnglish
Pages (from-to)1999-2008
Number of pages10
JournalSains Malaysiana
Volume47
Issue number9
DOIs
Publication statusPublished - 1 Jan 2018

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droplet
surfactant
water
turbidity
viscosity
index

Keywords

  • Cinnamaldehyde
  • Formation
  • High-pressure homogenisation
  • Nanoemulsion
  • Optimisation

ASJC Scopus subject areas

  • General

Cite this

Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design. / Sail, Asmawati M.; Wan Mustapha, Wan Aida; Mohamad Yusop, Salma; Maskat, Mohamad Yusof; Shamsuddin, Ahmad Fuad.

In: Sains Malaysiana, Vol. 47, No. 9, 01.01.2018, p. 1999-2008.

Research output: Contribution to journalArticle

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