Oligostilbenoids from Shorea gibbosa and their cytotoxic properties against P-388 cells

Haryoto Saroyobudiono, Lia D. Juliawaty, Yana M. Syah, Sjamsul A. Achmad, Euis H. Hakim, Jalifah Latip, Ikram M. Said

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A new oligostilbenoid derivative, diptoindonesin F (1), along with five known oligostilbenoids, (-)-ampelopsin A (2), (-)-α-viniferin (3), ampelopsin E (4), (-)-vaticanol B (5), and (-)-hemsleyanol D (6), were isolated from the methanol extract of the tree bark of Shorea gibbosa. The structure of the new compound was determined based on the analysis of spectroscopic data, including UV, IR, NMR 1-D and 2-D, and mass spectra. Cytotoxic properties of the isolated oligostilbenoids were evaluated against murine leukemia P-388 cells with the result that compounds 2 and 4 showed the highest cytotoxicity.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalJournal of Natural Medicines
Volume62
Issue number2
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Dipterocarpaceae
Plant Bark
Cytotoxicity
Methanol
Leukemia
Nuclear magnetic resonance
Derivatives
ampelopsin

Keywords

  • Cytotoxicity
  • Dipterocarpaceae
  • Diptoindonesin F
  • Oligostilbenoid
  • P-388 cells
  • Shorea gibbosa

ASJC Scopus subject areas

  • Organic Chemistry
  • Complementary and alternative medicine
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Saroyobudiono, H., Juliawaty, L. D., Syah, Y. M., Achmad, S. A., Hakim, E. H., Latip, J., & Said, I. M. (2008). Oligostilbenoids from Shorea gibbosa and their cytotoxic properties against P-388 cells. Journal of Natural Medicines, 62(2), 195-198. https://doi.org/10.1007/s11418-007-0205-0

Oligostilbenoids from Shorea gibbosa and their cytotoxic properties against P-388 cells. / Saroyobudiono, Haryoto; Juliawaty, Lia D.; Syah, Yana M.; Achmad, Sjamsul A.; Hakim, Euis H.; Latip, Jalifah; Said, Ikram M.

In: Journal of Natural Medicines, Vol. 62, No. 2, 04.2008, p. 195-198.

Research output: Contribution to journalArticle

Saroyobudiono, H, Juliawaty, LD, Syah, YM, Achmad, SA, Hakim, EH, Latip, J & Said, IM 2008, 'Oligostilbenoids from Shorea gibbosa and their cytotoxic properties against P-388 cells', Journal of Natural Medicines, vol. 62, no. 2, pp. 195-198. https://doi.org/10.1007/s11418-007-0205-0
Saroyobudiono, Haryoto ; Juliawaty, Lia D. ; Syah, Yana M. ; Achmad, Sjamsul A. ; Hakim, Euis H. ; Latip, Jalifah ; Said, Ikram M. / Oligostilbenoids from Shorea gibbosa and their cytotoxic properties against P-388 cells. In: Journal of Natural Medicines. 2008 ; Vol. 62, No. 2. pp. 195-198.
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