Oil palm phenolics (OPP) inhibit pancreatic cancer cell proliferation via suppression of NF-κB pathway

Xiangming Ji, Anee Usman, Nurul Huda Razalli, Ravigadevi Sambanthamurthi, Smiti V. Gupta

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Results: OPP suppressed PaCa proliferation in a dosedependent manner. Its anti-invasive effects were validated by decreased expressions of MMP-9 and VEGF. Cell-cycle analysis demonstrated that cells were arrested in the S phase. OPP-induced apoptosis was associated with decrease in survivin and Bcl-XL expressions and increased expression of cleaved caspase-3, caspase-9 and PARP.

Background: Oil palm phenolics (OPP) or Palm Juice (PJ), a water soluble extract from the palm fruit (Elaies guineensis) has been documented to have anticarcinogenic activities in various cancer types.

Materials and Methods: To investigate OPP effects in pancreatic cancer (PaCa) cells, two PaCa cell lines (PANC-1 and BxPC-3) were treated with different OPP doses. The antiproliferative, apoptotic and anti-invasive properties of OPP were evaluated using MTS, cytoplasmic histone-DNA fragmentation and matrigel invasive assays, respectively.

Conclusion: Overall, our results demonstrate the anti-tumor effects of OPP on PaCa cells, providing initial evidence towards its potential therapeutic use.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalAnticancer Research
Volume35
Issue number1
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Fingerprint

Pancreatic Neoplasms
Oils
Cell Proliferation
Caspase 9
Therapeutic Uses
DNA Fragmentation
Matrix Metalloproteinases
S Phase
Caspase 3
Histones
Vascular Endothelial Growth Factor A
Fruit
Neoplasms
Cell Cycle
Apoptosis
Cell Line
Water

Keywords

  • Apoptosis
  • NF-κB
  • Oil palm phenolics
  • Pancreatic cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Oil palm phenolics (OPP) inhibit pancreatic cancer cell proliferation via suppression of NF-κB pathway. / Ji, Xiangming; Usman, Anee; Razalli, Nurul Huda; Sambanthamurthi, Ravigadevi; Gupta, Smiti V.

In: Anticancer Research, Vol. 35, No. 1, 01.01.2015, p. 97-106.

Research output: Contribution to journalArticle

Ji, Xiangming ; Usman, Anee ; Razalli, Nurul Huda ; Sambanthamurthi, Ravigadevi ; Gupta, Smiti V. / Oil palm phenolics (OPP) inhibit pancreatic cancer cell proliferation via suppression of NF-κB pathway. In: Anticancer Research. 2015 ; Vol. 35, No. 1. pp. 97-106.
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