Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits

Che Anishas Che Idris, Tilakavati Karupaiah, Kalyana Sundram, Yew Ai Tan, Nagendran Balasundram, Soon Sen Leow, Nasruddin Nurrul Shaqinah, Ravigadevi Sambanthamurthi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The protective effects of oil palm vitamin E and phenolics against atherosclerosis, either singly or in combination, were studied in an atherogenic rabbit model. Rabbits were either fed atherogenic diet only (CTR), or atherogenic diet with vitamin E (VIT E), or atherogenic diet with oil palm phenolics (OPP), or atherogenic diet with both vitamin E and oil palm phenolics (VIT E. +. OPP). Results from lipid profile and antioxidant analyses were not significantly different between groups ( p>. 0.05). However, fibrous plaques were associated with the CTR group (8.90. ±. 5.41%) and these were significantly less ( p<. 0.05) in the VIT E (2.88. ±. 2.01%) and OPP (1.48. ±. 4.45%) groups. Fibrous plaques were not detected at all in the VIT E. +. OPP group. Our findings suggest that oil palm vitamin E and oil palm phenolics individually inhibited atherosclerotic lesion development. However, oil palm vitamin E in combination with oil palm phenolics provided the highest protective effect against development of atherosclerotic lesions.

Original languageEnglish
Pages (from-to)541-550
Number of pages10
JournalJournal of Functional Foods
Volume7
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Elaeis guineensis
atherosclerosis
Vitamin E
vitamin E
Atherosclerosis
Oils
rabbits
Rabbits
Atherogenic Diet
diet
lesions (animal)
protective effect
Antioxidants
Lipids
antioxidants

Keywords

  • Antioxidant activity
  • Atherosclerosis
  • Lipid profiles
  • Oil palm phenolics

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Che Idris, C. A., Karupaiah, T., Sundram, K., Tan, Y. A., Balasundram, N., Leow, S. S., ... Sambanthamurthi, R. (2014). Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits. Journal of Functional Foods, 7(1), 541-550. https://doi.org/10.1016/j.jff.2014.01.002

Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits. / Che Idris, Che Anishas; Karupaiah, Tilakavati; Sundram, Kalyana; Tan, Yew Ai; Balasundram, Nagendran; Leow, Soon Sen; Nurrul Shaqinah, Nasruddin; Sambanthamurthi, Ravigadevi.

In: Journal of Functional Foods, Vol. 7, No. 1, 2014, p. 541-550.

Research output: Contribution to journalArticle

Che Idris, CA, Karupaiah, T, Sundram, K, Tan, YA, Balasundram, N, Leow, SS, Nurrul Shaqinah, N & Sambanthamurthi, R 2014, 'Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits', Journal of Functional Foods, vol. 7, no. 1, pp. 541-550. https://doi.org/10.1016/j.jff.2014.01.002
Che Idris, Che Anishas ; Karupaiah, Tilakavati ; Sundram, Kalyana ; Tan, Yew Ai ; Balasundram, Nagendran ; Leow, Soon Sen ; Nurrul Shaqinah, Nasruddin ; Sambanthamurthi, Ravigadevi. / Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits. In: Journal of Functional Foods. 2014 ; Vol. 7, No. 1. pp. 541-550.
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