Oesophageal hepatoid carcinoma with liver metastasis, a diagnostic dilemma

Azyani Yahaya, Wan Syahira Wa Kammal, Nordashima Abd Shukor, Syazarina Sharis Osman

Research output: Contribution to journalArticle

Abstract

Alpha-fetoprotein (AFP)-producing carcinoma which microscopically mimics hepatocellular carcinoma (HCC) is a rare entity known as hepatoid adenocarcinoma (HC). They usually arise in the stomach, while oesophageal origin is only occasionally encountered. This tumour is highly aggressive and is associated with a poor prognosis. They frequently metastasise to the liver, thus giving rise to diagnostic difficulty, especially in cases where simultaneous oesophageal and liver mass are present. We reported a case of oesophageal hepatoid carcinoma with multiple liver metastasis, that was associated with an increased serum AFP. The distinction between HCC and HC is important because HC is more aggressive and has a poorer prognosis with limited therapeutic options. An extensive diagnostic work-up which include a thorough clinical history, radiological investigations (computed tomography or magnetic resonance imaging) as well as tissue biopsy supported by a panel of immunohistochemical markers are necessary to aid in the diagnosis of HC.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalMalaysian Journal of Pathology
Volume41
Issue number1
Publication statusPublished - Apr 2019

Fingerprint

alpha-Fetoproteins
Neoplasm Metastasis
Carcinoma
Hepatocellular Carcinoma
Liver
Stomach
Adenocarcinoma
Tomography
Magnetic Resonance Imaging
Biopsy
Serum
Neoplasms
Therapeutics

Keywords

  • Alpha-fetoprotein
  • Hepatocellular carcinoma
  • Hepatoid carcinoma
  • Oesophageal cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Oesophageal hepatoid carcinoma with liver metastasis, a diagnostic dilemma. / Yahaya, Azyani; Wa Kammal, Wan Syahira; Abd Shukor, Nordashima; Osman, Syazarina Sharis.

In: Malaysian Journal of Pathology, Vol. 41, No. 1, 04.2019, p. 59-63.

Research output: Contribution to journalArticle

Yahaya, A, Wa Kammal, WS, Abd Shukor, N & Osman, SS 2019, 'Oesophageal hepatoid carcinoma with liver metastasis, a diagnostic dilemma', Malaysian Journal of Pathology, vol. 41, no. 1, pp. 59-63.
Yahaya, Azyani ; Wa Kammal, Wan Syahira ; Abd Shukor, Nordashima ; Osman, Syazarina Sharis. / Oesophageal hepatoid carcinoma with liver metastasis, a diagnostic dilemma. In: Malaysian Journal of Pathology. 2019 ; Vol. 41, No. 1. pp. 59-63.
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