Abstract
Wegener's granulomatosis (newly renamed granulomatosis with polyangiitis [WG/GPA]) is a granulomatous autoimmune inflammatory disorder of unknown etiology that is associated with anti-neutrophil cytoplasm antibodies. It can involve any organ system, but most commonly affects the respiratory and renal systems and the head and neck, including the eye. The ophthalmic manifestations of WG/GPA are diverse and can affect any of the ocular structures. Despite continuing research, the exact pathogenesis of WG/GPA remains elusive, but there is increasing awareness of the disease, especially as its prevalence and incidence are both on the rise. Unhelpfully, the diagnosis and management of WG/GPA remains a challenge, especially in its limited form, as blood tests, imaging and tissue biopsies are often negative or nonspecific. Nevertheless, the emergence of new treatment regimens for WG/GPA, particularly target-specific drugs such as rituximab, the anti-CD20 antibody, is bringing promise in providing patients with better and potentially safer treatment for the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 541-555 |
| Number of pages | 15 |
| Journal | Expert Review of Ophthalmology |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2011 |
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Keywords
- Granulomata
- Ocular
- Rituximab
- Vasculitis
- Wegener's granulomatosis
ASJC Scopus subject areas
- Ophthalmology
- Biomedical Engineering
- Optometry
Cite this
Ocular manifestations of Wegener's granulomatosis. / Mohd Isa, Hazlita; Lightman, Susan; Pusey, Charles D.; Taylor, Simon Rj.
In: Expert Review of Ophthalmology, Vol. 6, No. 5, 10.2011, p. 541-555.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ocular manifestations of Wegener's granulomatosis
AU - Mohd Isa, Hazlita
AU - Lightman, Susan
AU - Pusey, Charles D.
AU - Taylor, Simon Rj
PY - 2011/10
Y1 - 2011/10
N2 - Wegener's granulomatosis (newly renamed granulomatosis with polyangiitis [WG/GPA]) is a granulomatous autoimmune inflammatory disorder of unknown etiology that is associated with anti-neutrophil cytoplasm antibodies. It can involve any organ system, but most commonly affects the respiratory and renal systems and the head and neck, including the eye. The ophthalmic manifestations of WG/GPA are diverse and can affect any of the ocular structures. Despite continuing research, the exact pathogenesis of WG/GPA remains elusive, but there is increasing awareness of the disease, especially as its prevalence and incidence are both on the rise. Unhelpfully, the diagnosis and management of WG/GPA remains a challenge, especially in its limited form, as blood tests, imaging and tissue biopsies are often negative or nonspecific. Nevertheless, the emergence of new treatment regimens for WG/GPA, particularly target-specific drugs such as rituximab, the anti-CD20 antibody, is bringing promise in providing patients with better and potentially safer treatment for the disease.
AB - Wegener's granulomatosis (newly renamed granulomatosis with polyangiitis [WG/GPA]) is a granulomatous autoimmune inflammatory disorder of unknown etiology that is associated with anti-neutrophil cytoplasm antibodies. It can involve any organ system, but most commonly affects the respiratory and renal systems and the head and neck, including the eye. The ophthalmic manifestations of WG/GPA are diverse and can affect any of the ocular structures. Despite continuing research, the exact pathogenesis of WG/GPA remains elusive, but there is increasing awareness of the disease, especially as its prevalence and incidence are both on the rise. Unhelpfully, the diagnosis and management of WG/GPA remains a challenge, especially in its limited form, as blood tests, imaging and tissue biopsies are often negative or nonspecific. Nevertheless, the emergence of new treatment regimens for WG/GPA, particularly target-specific drugs such as rituximab, the anti-CD20 antibody, is bringing promise in providing patients with better and potentially safer treatment for the disease.
KW - Granulomata
KW - Ocular
KW - Rituximab
KW - Vasculitis
KW - Wegener's granulomatosis
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U2 - 10.1586/eop.11.62
DO - 10.1586/eop.11.62
M3 - Article
VL - 6
SP - 541
EP - 555
JO - Expert Review of Respiratory Medicine
JF - Expert Review of Respiratory Medicine
SN - 1747-6348
IS - 5
ER -