Obstructive jaundice in small cell lung carcinoma

Ali Mokhtar Pour, Noraidah Masir, Mohd Rose Isa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Small cell lung carcinoma (SCLC) commonly metastasizes to distant organs. However, metastasis to the pancreas is not a common event. Moreover, obstructive jaundice as a first clinical presentation of SCLC is extremely unusual. This case reports a 51-year-old male with SCLC, manifesting with obstructive jaundice as the initial clinical presentation. Endoscopic retrograde cholangiopancreatograghy (ERCP) and abdominal computed tomography (CT) scan showed a mass at the head of the pancreas. The patient underwent pancreatoduodenectomy (Whipple procedure). Histopathology revealed a chromogranin- A-positive poorly-differentiated neuroendocrine carcinoma of the pancreas. No imaging study of the lung was performed before surgery. A few months later, a follow-up CT revealed unilateral lung nodules with ipsilateral hilar nodes. A lung biopsy was done and histopathology reported a TTF- 1-positive, chromogranin A-positive, small cell carcinoma of the lung. On review, the pancreatic tumour was also TTF-1-positive. He was then treated with combination chemotherapy (cisplatin, etoposide). These findings highlight that presentation of a mass at the head of pancreas could be a manifestation of a metastatic tumour from elsewhere such as the lung, and thorough investigations should be performed before metastases can be ruled out.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalMalaysian Journal of Pathology
Volume37
Issue number2
Publication statusPublished - 1 Aug 2015

Fingerprint

Obstructive Jaundice
Small Cell Lung Carcinoma
Pancreas
Chromogranin A
Lung
Tomography
Neoplasm Metastasis
Neuroendocrine Carcinoma
Pancreaticoduodenectomy
Etoposide
Combination Drug Therapy
Cisplatin
Neoplasms
Biopsy

Keywords

  • Lung
  • Metastasis
  • Obstructive jaundice
  • Pancreas
  • Small cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Histology

Cite this

Obstructive jaundice in small cell lung carcinoma. / Mokhtar Pour, Ali; Masir, Noraidah; Isa, Mohd Rose.

In: Malaysian Journal of Pathology, Vol. 37, No. 2, 01.08.2015, p. 149-152.

Research output: Contribution to journalArticle

Mokhtar Pour, A, Masir, N & Isa, MR 2015, 'Obstructive jaundice in small cell lung carcinoma', Malaysian Journal of Pathology, vol. 37, no. 2, pp. 149-152.
Mokhtar Pour, Ali ; Masir, Noraidah ; Isa, Mohd Rose. / Obstructive jaundice in small cell lung carcinoma. In: Malaysian Journal of Pathology. 2015 ; Vol. 37, No. 2. pp. 149-152.
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