Obesity indices and metabolic markers are related to hs-CRP and adiponectin levels in overweight and obese females

Zulkefli Sanip, Farah Diana Ariffin, Belqes Abdullah Mohammed Al-Tahami, Wan Azman Wan Sulaiman, Aida Hanum Ghulam Rasool

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Obese subjects had increased serum high sensitivity C-reactive protein (hs-CRP), decreased adiponectin levels, and impaired microvascular endothelial function compared to lean subjects. We investigated the relationships of serum hs-CRP, adiponectin and microvascular endothelial function with obesity indices and metabolic markers in overweight and obese female subjects. Anthropometric profile, body fat composition, biochemical analysis, serum hs-CRP and adiponectin levels, and microvascular endothelial function were measured in 91 female subjects. Microvascular endothelial function was determined using laser Doppler fluximetry and the process of iontophoresis. Mean age and body mass index (BMI) of subjects were 34.88 (7.87) years and 32.93 (4.82) kg/m 2. hs-CRP levels were positively correlated with weight, BMI, waist circumference, hip circumference, body fat and visceral fat. Adiponectin levels were positively correlated with insulin sensitivity index (HOMA-%S), and inversely correlated with waist hip ratio, triglyceride, fasting insulin and insulin resistance index (HOMA-IR). No relationship was seen between microvascular endothelial function and obesity indices, and metabolic markers. In overweight and obese female subjects, hs-CRP levels were correlated with obesity indices while adiponectin levels were inversely correlated with obesity indices and metabolic markers. No significant relationship was seen between microvascular endothelial function with obesity indices and metabolic markers including hs-CRP and adiponectin in female overweight and obese subjects.

Original languageEnglish
JournalObesity Research and Clinical Practice
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

Fingerprint

Adiponectin
C-Reactive Protein
Obesity
Insulin Resistance
Adipose Tissue
Body Mass Index
Serum
Iontophoresis
Waist-Hip Ratio
Intra-Abdominal Fat
Waist Circumference
Body Composition
Hip
Fasting
Triglycerides
Lasers
Insulin
Weights and Measures

Keywords

  • Adiponectin
  • hs-CRP
  • Insulin sensitivity
  • Microvascular endothelial function
  • Obesity indices

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Obesity indices and metabolic markers are related to hs-CRP and adiponectin levels in overweight and obese females. / Sanip, Zulkefli; Ariffin, Farah Diana; Al-Tahami, Belqes Abdullah Mohammed; Sulaiman, Wan Azman Wan; Rasool, Aida Hanum Ghulam.

In: Obesity Research and Clinical Practice, Vol. 7, No. 4, 07.2013.

Research output: Contribution to journalArticle

Sanip, Zulkefli ; Ariffin, Farah Diana ; Al-Tahami, Belqes Abdullah Mohammed ; Sulaiman, Wan Azman Wan ; Rasool, Aida Hanum Ghulam. / Obesity indices and metabolic markers are related to hs-CRP and adiponectin levels in overweight and obese females. In: Obesity Research and Clinical Practice. 2013 ; Vol. 7, No. 4.
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