Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding

Samantha Scholtz, Alexander D. Miras, Navpreet Chhina, Christina G. Prechtl, Michelle L. Sleeth, Norlida Mat Daud @ Daud, Nurhafzan A. Ismail, Giuliana Durighel, Ahmed R. Ahmed, Torsten Olbers, Royce P. Vincent, Jamshid Alaghband-Zadeh, Mohammad A. Ghatei, Adam D. Waldman, Gary S. Frost, Jimmy D. Bell, Carel W. Le Roux, Anthony P. Goldstone

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Objectives: Roux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations. Design: We used functional MRI, eating behaviour and hormonal phenotyping to compare body mass index (BMI)-matched unoperated controls and patients after RYGB and BAND surgery for obesity. Results: Obese patients after RYGB had lower brain-hedonic responses to food than patients after BAND surgery. RYGB patients had lower activation than BAND patients in brain reward systems, particularly to high-calorie foods, including the orbitofrontal cortex, amygdala, caudate nucleus, nucleus accumbens and hippocampus. This was associated with lower palatability and appeal of high-calorie foods and healthier eating behaviour, including less fat intake, in RYGB compared with BAND patients and/or BMI-matched unoperated controls. These differences were not explicable by differences in hunger or psychological traits between the surgical groups, but anorexigenic plasma gut hormones (GLP-1 and PYY), plasma bile acids and symptoms of dumping syndrome were increased in RYGB patients. Conclusions: The identification of these differences in food hedonic responses as a result of altered gut anatomy/physiology provides a novel explanation for the more favourable long-term weight loss seen after RYGB than after BAND surgery, highlighting the importance of the gut-brain axis in the control of reward-based eating behaviour.

Original languageEnglish
Pages (from-to)891-902
Number of pages12
JournalGut
Volume63
Issue number6
DOIs
Publication statusPublished - 1 Jun 2014
Externally publishedYes

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Pleasure
Gastric Bypass
Stomach
Food
Brain
Feeding Behavior
Reward
Weight Loss
Anatomy
Body Mass Index
Dumping Syndrome
Glucagon-Like Peptide 1
Hunger
Caudate Nucleus
Nucleus Accumbens
Amygdala
Prefrontal Cortex
Bile Acids and Salts
Hippocampus
Obesity

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding. / Scholtz, Samantha; Miras, Alexander D.; Chhina, Navpreet; Prechtl, Christina G.; Sleeth, Michelle L.; Mat Daud @ Daud, Norlida; Ismail, Nurhafzan A.; Durighel, Giuliana; Ahmed, Ahmed R.; Olbers, Torsten; Vincent, Royce P.; Alaghband-Zadeh, Jamshid; Ghatei, Mohammad A.; Waldman, Adam D.; Frost, Gary S.; Bell, Jimmy D.; Le Roux, Carel W.; Goldstone, Anthony P.

In: Gut, Vol. 63, No. 6, 01.06.2014, p. 891-902.

Research output: Contribution to journalArticle

Scholtz, S, Miras, AD, Chhina, N, Prechtl, CG, Sleeth, ML, Mat Daud @ Daud, N, Ismail, NA, Durighel, G, Ahmed, AR, Olbers, T, Vincent, RP, Alaghband-Zadeh, J, Ghatei, MA, Waldman, AD, Frost, GS, Bell, JD, Le Roux, CW & Goldstone, AP 2014, 'Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding', Gut, vol. 63, no. 6, pp. 891-902. https://doi.org/10.1136/gutjnl-2013-305008
Scholtz, Samantha ; Miras, Alexander D. ; Chhina, Navpreet ; Prechtl, Christina G. ; Sleeth, Michelle L. ; Mat Daud @ Daud, Norlida ; Ismail, Nurhafzan A. ; Durighel, Giuliana ; Ahmed, Ahmed R. ; Olbers, Torsten ; Vincent, Royce P. ; Alaghband-Zadeh, Jamshid ; Ghatei, Mohammad A. ; Waldman, Adam D. ; Frost, Gary S. ; Bell, Jimmy D. ; Le Roux, Carel W. ; Goldstone, Anthony P. / Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding. In: Gut. 2014 ; Vol. 63, No. 6. pp. 891-902.
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abstract = "Objectives: Roux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations. Design: We used functional MRI, eating behaviour and hormonal phenotyping to compare body mass index (BMI)-matched unoperated controls and patients after RYGB and BAND surgery for obesity. Results: Obese patients after RYGB had lower brain-hedonic responses to food than patients after BAND surgery. RYGB patients had lower activation than BAND patients in brain reward systems, particularly to high-calorie foods, including the orbitofrontal cortex, amygdala, caudate nucleus, nucleus accumbens and hippocampus. This was associated with lower palatability and appeal of high-calorie foods and healthier eating behaviour, including less fat intake, in RYGB compared with BAND patients and/or BMI-matched unoperated controls. These differences were not explicable by differences in hunger or psychological traits between the surgical groups, but anorexigenic plasma gut hormones (GLP-1 and PYY), plasma bile acids and symptoms of dumping syndrome were increased in RYGB patients. Conclusions: The identification of these differences in food hedonic responses as a result of altered gut anatomy/physiology provides a novel explanation for the more favourable long-term weight loss seen after RYGB than after BAND surgery, highlighting the importance of the gut-brain axis in the control of reward-based eating behaviour.",
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T1 - Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding

AU - Scholtz, Samantha

AU - Miras, Alexander D.

AU - Chhina, Navpreet

AU - Prechtl, Christina G.

AU - Sleeth, Michelle L.

AU - Mat Daud @ Daud, Norlida

AU - Ismail, Nurhafzan A.

AU - Durighel, Giuliana

AU - Ahmed, Ahmed R.

AU - Olbers, Torsten

AU - Vincent, Royce P.

AU - Alaghband-Zadeh, Jamshid

AU - Ghatei, Mohammad A.

AU - Waldman, Adam D.

AU - Frost, Gary S.

AU - Bell, Jimmy D.

AU - Le Roux, Carel W.

AU - Goldstone, Anthony P.

PY - 2014/6/1

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N2 - Objectives: Roux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations. Design: We used functional MRI, eating behaviour and hormonal phenotyping to compare body mass index (BMI)-matched unoperated controls and patients after RYGB and BAND surgery for obesity. Results: Obese patients after RYGB had lower brain-hedonic responses to food than patients after BAND surgery. RYGB patients had lower activation than BAND patients in brain reward systems, particularly to high-calorie foods, including the orbitofrontal cortex, amygdala, caudate nucleus, nucleus accumbens and hippocampus. This was associated with lower palatability and appeal of high-calorie foods and healthier eating behaviour, including less fat intake, in RYGB compared with BAND patients and/or BMI-matched unoperated controls. These differences were not explicable by differences in hunger or psychological traits between the surgical groups, but anorexigenic plasma gut hormones (GLP-1 and PYY), plasma bile acids and symptoms of dumping syndrome were increased in RYGB patients. Conclusions: The identification of these differences in food hedonic responses as a result of altered gut anatomy/physiology provides a novel explanation for the more favourable long-term weight loss seen after RYGB than after BAND surgery, highlighting the importance of the gut-brain axis in the control of reward-based eating behaviour.

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