O-092. Ethnic differences in the baseline serum micronutrients and the prevalence of oral precancer/cancer in quid chewers

R. B. Zairr, Z. A A Rahmatr, N. Ikeda, P. Shanmuhasuntharam, H. Fukano, Z. Abang, R. A. Raman, T. Nagao, A. R. Samsuddin, M. N. Ghazali, M. Yano, I. A. Razak, H. Miyazaki, Y. Ito

Research output: Contribution to journalArticle

Abstract

Aims: (1) To compare the prevalence of oral cancer and precancer (OPC) among subjects with and without quid chewing habits and (2) To compare the baseline levels of some serum micronutrients in three ethnic groups in Malaysia namely the Indians, the Other Bumiputra of Sarawak (OBS) and the Malays. Method: A total of 1451 (I = 561, OBS = 614, M = 276) subjects were screened for OPC and their smoking/chewing/alcohol habits compared. Out of those screened, 322 subjects (I = 60, IPS = 91, M = 171) with no oral lesions were selected for comparison of their baseline serum retinol (RE), alpha-tocopherol (AT) and carotenoids. Blood samples were collected from the subjects (with informed consents) for analysis of retinol (RE), alphatocopherol/vitamin E (AT) and some carotenoids (lycopene [LYC], zeaxanthin/lutein [ZX/LU], cryptoxanthin [CRY], alpha-carotene [AC] and beta-carotene [BC]). Results: The prevalence of OPC among quid chewers was 31.3% for Indians, 11.9% for OBS and 1.9% for Malays. The Malays had the highest level of AT, AC, CRY and LYC; the OBS had the highest level of ZX/LU and BC while the Indians had the lowest levels of AT, AC (P < 0.001). Some carotenoids and AT were found to be lower in the habits group. Conclusions: The lower baseline levels of some carotenoids in the Indians as compared to the OBS and the Malays may partly explain the higher OPC prevalence in the Indians as compared to the OBS and the Malays. Lowering of some carotenoids with oral habits may further explain the high OPC prevalence in the Indians as compared to the OBS and the Malays since many of the OPCs in Malaysians were habit related.

Original languageEnglish
JournalOral Oncology
Volume37
Issue numberSUPPL. 1
Publication statusPublished - 2001
Externally publishedYes

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Micronutrients
Mouth Neoplasms
Malaysia
alpha-Tocopherol
Carotenoids
Habits
Serum
Lutein
Mastication
beta Carotene
Vitamin A
Informed Consent
Vitamin E
Ethnic Groups
Smoking
Alcohols

ASJC Scopus subject areas

  • Oncology

Cite this

Zairr, R. B., Rahmatr, Z. A. A., Ikeda, N., Shanmuhasuntharam, P., Fukano, H., Abang, Z., ... Ito, Y. (2001). O-092. Ethnic differences in the baseline serum micronutrients and the prevalence of oral precancer/cancer in quid chewers. Oral Oncology, 37(SUPPL. 1).

O-092. Ethnic differences in the baseline serum micronutrients and the prevalence of oral precancer/cancer in quid chewers. / Zairr, R. B.; Rahmatr, Z. A A; Ikeda, N.; Shanmuhasuntharam, P.; Fukano, H.; Abang, Z.; Raman, R. A.; Nagao, T.; Samsuddin, A. R.; Ghazali, M. N.; Yano, M.; Razak, I. A.; Miyazaki, H.; Ito, Y.

In: Oral Oncology, Vol. 37, No. SUPPL. 1, 2001.

Research output: Contribution to journalArticle

Zairr, RB, Rahmatr, ZAA, Ikeda, N, Shanmuhasuntharam, P, Fukano, H, Abang, Z, Raman, RA, Nagao, T, Samsuddin, AR, Ghazali, MN, Yano, M, Razak, IA, Miyazaki, H & Ito, Y 2001, 'O-092. Ethnic differences in the baseline serum micronutrients and the prevalence of oral precancer/cancer in quid chewers', Oral Oncology, vol. 37, no. SUPPL. 1.
Zairr RB, Rahmatr ZAA, Ikeda N, Shanmuhasuntharam P, Fukano H, Abang Z et al. O-092. Ethnic differences in the baseline serum micronutrients and the prevalence of oral precancer/cancer in quid chewers. Oral Oncology. 2001;37(SUPPL. 1).
Zairr, R. B. ; Rahmatr, Z. A A ; Ikeda, N. ; Shanmuhasuntharam, P. ; Fukano, H. ; Abang, Z. ; Raman, R. A. ; Nagao, T. ; Samsuddin, A. R. ; Ghazali, M. N. ; Yano, M. ; Razak, I. A. ; Miyazaki, H. ; Ito, Y. / O-092. Ethnic differences in the baseline serum micronutrients and the prevalence of oral precancer/cancer in quid chewers. In: Oral Oncology. 2001 ; Vol. 37, No. SUPPL. 1.
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abstract = "Aims: (1) To compare the prevalence of oral cancer and precancer (OPC) among subjects with and without quid chewing habits and (2) To compare the baseline levels of some serum micronutrients in three ethnic groups in Malaysia namely the Indians, the Other Bumiputra of Sarawak (OBS) and the Malays. Method: A total of 1451 (I = 561, OBS = 614, M = 276) subjects were screened for OPC and their smoking/chewing/alcohol habits compared. Out of those screened, 322 subjects (I = 60, IPS = 91, M = 171) with no oral lesions were selected for comparison of their baseline serum retinol (RE), alpha-tocopherol (AT) and carotenoids. Blood samples were collected from the subjects (with informed consents) for analysis of retinol (RE), alphatocopherol/vitamin E (AT) and some carotenoids (lycopene [LYC], zeaxanthin/lutein [ZX/LU], cryptoxanthin [CRY], alpha-carotene [AC] and beta-carotene [BC]). Results: The prevalence of OPC among quid chewers was 31.3{\%} for Indians, 11.9{\%} for OBS and 1.9{\%} for Malays. The Malays had the highest level of AT, AC, CRY and LYC; the OBS had the highest level of ZX/LU and BC while the Indians had the lowest levels of AT, AC (P < 0.001). Some carotenoids and AT were found to be lower in the habits group. Conclusions: The lower baseline levels of some carotenoids in the Indians as compared to the OBS and the Malays may partly explain the higher OPC prevalence in the Indians as compared to the OBS and the Malays. Lowering of some carotenoids with oral habits may further explain the high OPC prevalence in the Indians as compared to the OBS and the Malays since many of the OPCs in Malaysians were habit related.",
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T1 - O-092. Ethnic differences in the baseline serum micronutrients and the prevalence of oral precancer/cancer in quid chewers

AU - Zairr, R. B.

AU - Rahmatr, Z. A A

AU - Ikeda, N.

AU - Shanmuhasuntharam, P.

AU - Fukano, H.

AU - Abang, Z.

AU - Raman, R. A.

AU - Nagao, T.

AU - Samsuddin, A. R.

AU - Ghazali, M. N.

AU - Yano, M.

AU - Razak, I. A.

AU - Miyazaki, H.

AU - Ito, Y.

PY - 2001

Y1 - 2001

N2 - Aims: (1) To compare the prevalence of oral cancer and precancer (OPC) among subjects with and without quid chewing habits and (2) To compare the baseline levels of some serum micronutrients in three ethnic groups in Malaysia namely the Indians, the Other Bumiputra of Sarawak (OBS) and the Malays. Method: A total of 1451 (I = 561, OBS = 614, M = 276) subjects were screened for OPC and their smoking/chewing/alcohol habits compared. Out of those screened, 322 subjects (I = 60, IPS = 91, M = 171) with no oral lesions were selected for comparison of their baseline serum retinol (RE), alpha-tocopherol (AT) and carotenoids. Blood samples were collected from the subjects (with informed consents) for analysis of retinol (RE), alphatocopherol/vitamin E (AT) and some carotenoids (lycopene [LYC], zeaxanthin/lutein [ZX/LU], cryptoxanthin [CRY], alpha-carotene [AC] and beta-carotene [BC]). Results: The prevalence of OPC among quid chewers was 31.3% for Indians, 11.9% for OBS and 1.9% for Malays. The Malays had the highest level of AT, AC, CRY and LYC; the OBS had the highest level of ZX/LU and BC while the Indians had the lowest levels of AT, AC (P < 0.001). Some carotenoids and AT were found to be lower in the habits group. Conclusions: The lower baseline levels of some carotenoids in the Indians as compared to the OBS and the Malays may partly explain the higher OPC prevalence in the Indians as compared to the OBS and the Malays. Lowering of some carotenoids with oral habits may further explain the high OPC prevalence in the Indians as compared to the OBS and the Malays since many of the OPCs in Malaysians were habit related.

AB - Aims: (1) To compare the prevalence of oral cancer and precancer (OPC) among subjects with and without quid chewing habits and (2) To compare the baseline levels of some serum micronutrients in three ethnic groups in Malaysia namely the Indians, the Other Bumiputra of Sarawak (OBS) and the Malays. Method: A total of 1451 (I = 561, OBS = 614, M = 276) subjects were screened for OPC and their smoking/chewing/alcohol habits compared. Out of those screened, 322 subjects (I = 60, IPS = 91, M = 171) with no oral lesions were selected for comparison of their baseline serum retinol (RE), alpha-tocopherol (AT) and carotenoids. Blood samples were collected from the subjects (with informed consents) for analysis of retinol (RE), alphatocopherol/vitamin E (AT) and some carotenoids (lycopene [LYC], zeaxanthin/lutein [ZX/LU], cryptoxanthin [CRY], alpha-carotene [AC] and beta-carotene [BC]). Results: The prevalence of OPC among quid chewers was 31.3% for Indians, 11.9% for OBS and 1.9% for Malays. The Malays had the highest level of AT, AC, CRY and LYC; the OBS had the highest level of ZX/LU and BC while the Indians had the lowest levels of AT, AC (P < 0.001). Some carotenoids and AT were found to be lower in the habits group. Conclusions: The lower baseline levels of some carotenoids in the Indians as compared to the OBS and the Malays may partly explain the higher OPC prevalence in the Indians as compared to the OBS and the Malays. Lowering of some carotenoids with oral habits may further explain the high OPC prevalence in the Indians as compared to the OBS and the Malays since many of the OPCs in Malaysians were habit related.

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