Novel triazole 2'-deoxy-4'-thionucleosides: Stereoselective synthesis and biological evaluation

G. Inguaggiato, Malina Jasamai, J. E. Smith, M. Slater, C. Simons

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A study on the use of protecting groups led to the employment of the paramethoxybenzoyl (pMB) group as a directing group in the synthesis of novel triazole 2'-deoxy-4'-thionucleosides. Use of the pMB group gave α:β ratios of 1:6 in the glycosylation step with azidotrimethylsilane. A series of novel triazoles were generated for in vitro antiviral evaluation.

Original languageEnglish
Pages (from-to)457-467
Number of pages11
JournalNucleosides and Nucleotides
Volume18
Issue number3
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Thionucleosides
Triazoles
Glycosylation
Antiviral Agents

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

Novel triazole 2'-deoxy-4'-thionucleosides : Stereoselective synthesis and biological evaluation. / Inguaggiato, G.; Jasamai, Malina; Smith, J. E.; Slater, M.; Simons, C.

In: Nucleosides and Nucleotides, Vol. 18, No. 3, 1999, p. 457-467.

Research output: Contribution to journalArticle

Inguaggiato, G. ; Jasamai, Malina ; Smith, J. E. ; Slater, M. ; Simons, C. / Novel triazole 2'-deoxy-4'-thionucleosides : Stereoselective synthesis and biological evaluation. In: Nucleosides and Nucleotides. 1999 ; Vol. 18, No. 3. pp. 457-467.
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