Novel sesquiterpene and copyrine alkaloids from Anaxagorea javanica Blume

Khairana Husain, Siti Mariam Zakaria, Nordin H. Lajis, Khozirah Shaari, Intan Safinar Ismail, Daud A. Israf, Christian Paetz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A novel sesquiterpene, nordine (or 2,2,9-trimethyl-5-methylene-12-oxa- bicyclo[6.3.1]dodecane-4,9-diol) (1) and two new copyrine alkaloids of eupolauridine skeleton, viz., 4,11-dimethoxyeupolauridine (2) and 2-methoxy-3-hydroxyeupolauridine (3), along with five alkaloidal (4-8) and nine non-alkaloidal compounds (9-17), have been isolated from the bark and roots of Anaxagorea javanica Blume. The structures of the new constituents were deduced by NMR spectral data. Compounds 6 and 7 displayed moderate inhibition of NO production with IC50 values of 18.2 and 32.3 μg/ml respectively.

Original languageEnglish
Pages (from-to)788-792
Number of pages5
JournalPhytochemistry Letters
Volume5
Issue number4
DOIs
Publication statusPublished - Dec 2012

Fingerprint

glycols
Sesquiterpenes
Alkaloids
Skeleton
sesquiterpenoids
spectral analysis
Inhibitory Concentration 50
skeleton
inhibitory concentration 50
alkaloids
bark
Nuclear magnetic resonance
eupolauridine
n-dodecane
compound 17

Keywords

  • Anaxagorea javanica Blume
  • Annonaceae
  • Copyrine alkaloids
  • Eupolauridine skeletal system
  • Sesquiterpene

ASJC Scopus subject areas

  • Plant Science
  • Agronomy and Crop Science
  • Biochemistry
  • Biotechnology

Cite this

Husain, K., Zakaria, S. M., Lajis, N. H., Shaari, K., Ismail, I. S., Israf, D. A., & Paetz, C. (2012). Novel sesquiterpene and copyrine alkaloids from Anaxagorea javanica Blume. Phytochemistry Letters, 5(4), 788-792. https://doi.org/10.1016/j.phytol.2012.09.003

Novel sesquiterpene and copyrine alkaloids from Anaxagorea javanica Blume. / Husain, Khairana; Zakaria, Siti Mariam; Lajis, Nordin H.; Shaari, Khozirah; Ismail, Intan Safinar; Israf, Daud A.; Paetz, Christian.

In: Phytochemistry Letters, Vol. 5, No. 4, 12.2012, p. 788-792.

Research output: Contribution to journalArticle

Husain, K, Zakaria, SM, Lajis, NH, Shaari, K, Ismail, IS, Israf, DA & Paetz, C 2012, 'Novel sesquiterpene and copyrine alkaloids from Anaxagorea javanica Blume', Phytochemistry Letters, vol. 5, no. 4, pp. 788-792. https://doi.org/10.1016/j.phytol.2012.09.003
Husain, Khairana ; Zakaria, Siti Mariam ; Lajis, Nordin H. ; Shaari, Khozirah ; Ismail, Intan Safinar ; Israf, Daud A. ; Paetz, Christian. / Novel sesquiterpene and copyrine alkaloids from Anaxagorea javanica Blume. In: Phytochemistry Letters. 2012 ; Vol. 5, No. 4. pp. 788-792.
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