Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer

Hui Wen Lo, Weiya Xia, Yongkun Wei, Mohamed Ali-Seyed, Shiu Feng Huang, Mien Chie Hung

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Epidermal growth factor receptor (EGFR) has been detected in the nucleus of cancer cells and primary tumors for decades. While localized in the nucleus, EGFR functions as a transcriptional regulator resulting in the activation of the cyclin D1 gene. Despite nuclear accumulation of EGFR is linked to increased DNA synthesis and proliferative potential, the pathological significance of nuclear EGFR, however, remains uninvestigated. Furthermore, expression of EGFR has not provided a consistent predictive value for survival of breast cancer patients. Here, we analyzed 130 breast carcinomas via immunohistochemical analyses for the levels of nuclear and non-nuclear EGFR. We found 37.7% of the cohort immunostained positively for nuclear EGFR and 6.9% with high levels of expression. Importantly, Kaplan-Meier survival analysis and log-rank test revealed a significant inverse correlation between high nuclear EGFR and overall survival (P = 0.009). Expression of nuclear EGFR correlated positively with increased levels of cyclin D1 and Ki-67, both are indicators for cell proliferation. In contrast, expression of non-nuclear EGFR did not significantly correlate with those of cyclin D1 and Ki-67 or the overall survival rate. In addition, we analyzed 37 oral squamous carcinomas for EGFR expression and found 24.3% of the cases to contain moderate/high levels of nuclear EGFR. Taken together, our findings indicate pathological significance of nuclear EGFR and may have important clinical implication.

Original languageEnglish
Pages (from-to)338-348
Number of pages11
JournalCancer Research
Volume65
Issue number1
Publication statusPublished - 1 Jan 2005
Externally publishedYes

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Epidermal Growth Factor Receptor
Breast Neoplasms
Cyclin D1
bcl-1 Genes
Survival
Kaplan-Meier Estimate
Survival Analysis
Cell Nucleus
Squamous Cell Carcinoma
Neoplasms
Survival Rate
Cell Proliferation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lo, H. W., Xia, W., Wei, Y., Ali-Seyed, M., Huang, S. F., & Hung, M. C. (2005). Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Research, 65(1), 338-348.

Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. / Lo, Hui Wen; Xia, Weiya; Wei, Yongkun; Ali-Seyed, Mohamed; Huang, Shiu Feng; Hung, Mien Chie.

In: Cancer Research, Vol. 65, No. 1, 01.01.2005, p. 338-348.

Research output: Contribution to journalArticle

Lo, HW, Xia, W, Wei, Y, Ali-Seyed, M, Huang, SF & Hung, MC 2005, 'Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer', Cancer Research, vol. 65, no. 1, pp. 338-348.
Lo HW, Xia W, Wei Y, Ali-Seyed M, Huang SF, Hung MC. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Research. 2005 Jan 1;65(1):338-348.
Lo, Hui Wen ; Xia, Weiya ; Wei, Yongkun ; Ali-Seyed, Mohamed ; Huang, Shiu Feng ; Hung, Mien Chie. / Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. In: Cancer Research. 2005 ; Vol. 65, No. 1. pp. 338-348.
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