Novel antioxidants compounds derived from isatine

Dunia Lafta Al-Duhaidahawi, Majid S. Jabir, Ahmed A. Al-Amiery, Ahmed E.Abdel Moneim, Ayad F. Alkaim, Abdul Amir H. Kadhum

Research output: Contribution to journalArticle

Abstract

Isatin was first synthesized in 1841 by Erdmann and Laurent by the oxition reaction of indigo dye by an oxiizing agent nitric acid/chromic acid. It was found in many plants, like Isatis tinctoria, Calanthe discolor and in cannonball tree. Isatin- azomethine had been studied for their important medicinal applications.The syntheses of Isatinazomethines, that are quite compulsory pharmaceutical properties because of their structurally motivating antioxidant activities. Isatin - azomethines had been synthesized effectively via the reaction of Isatinwithvarious amins. Various spectroscopicaltechniqes were used to characterized the synthesized Isatins. The antioxidant capacity of Isatin-azomethines were predestined by representative spectroscopically techniques, employing radical's DPPH (2,2-diphenyl-1- picrylhydrazyl), FRAP (Ferric Reducing Antioxidant Power) and Ferrous ions chelating activity assays compared to that of ascorbic acid. Isatin-azomethines displayed an superior scavenging activities paralleled to the ascorbic acid.

Original languageEnglish
Pages (from-to)709-713
Number of pages5
JournalBiochemical and Cellular Archives
Volume18
Issue number1
Publication statusPublished - 1 Jan 2018

Fingerprint

Isatin
Antioxidants
Ascorbic Acid
Isatis
Indigo Carmine
Nitric Acid
Scavenging
Chelation
Assays
Coloring Agents
Ions
Pharmaceutical Preparations

Keywords

  • Ferrous ions
  • Hydrogen peroxide
  • Isatin-azomethines
  • Scavengers

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Al-Duhaidahawi, D. L., Jabir, M. S., Al-Amiery, A. A., Moneim, A. E. A., Alkaim, A. F., & Kadhum, A. A. H. (2018). Novel antioxidants compounds derived from isatine. Biochemical and Cellular Archives, 18(1), 709-713.

Novel antioxidants compounds derived from isatine. / Al-Duhaidahawi, Dunia Lafta; Jabir, Majid S.; Al-Amiery, Ahmed A.; Moneim, Ahmed E.Abdel; Alkaim, Ayad F.; Kadhum, Abdul Amir H.

In: Biochemical and Cellular Archives, Vol. 18, No. 1, 01.01.2018, p. 709-713.

Research output: Contribution to journalArticle

Al-Duhaidahawi, DL, Jabir, MS, Al-Amiery, AA, Moneim, AEA, Alkaim, AF & Kadhum, AAH 2018, 'Novel antioxidants compounds derived from isatine', Biochemical and Cellular Archives, vol. 18, no. 1, pp. 709-713.
Al-Duhaidahawi DL, Jabir MS, Al-Amiery AA, Moneim AEA, Alkaim AF, Kadhum AAH. Novel antioxidants compounds derived from isatine. Biochemical and Cellular Archives. 2018 Jan 1;18(1):709-713.
Al-Duhaidahawi, Dunia Lafta ; Jabir, Majid S. ; Al-Amiery, Ahmed A. ; Moneim, Ahmed E.Abdel ; Alkaim, Ayad F. ; Kadhum, Abdul Amir H. / Novel antioxidants compounds derived from isatine. In: Biochemical and Cellular Archives. 2018 ; Vol. 18, No. 1. pp. 709-713.
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