Notch signalling pathways and their importance in the treatment of cancers

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Background: The Notch pathway is an evolutionarily conserved, intercellular signalling system which is present in all multicellular organisms and mammals. The Notch pathway plays an important role in the embryonic development as it controls cell proliferation, cell differentiation and binary cell fate decisions. Objective: In the present review, we highlight the Notch signalling pathway components i.e. Notch receptors, ligands, effector, and their regulators. We also discuss the tumor biology of the Notch pathway involved in various cancers. Results: Interestingly, the Notch signalling pathway is dysregulated in many cancers. Notch may serve as oncogene or tumor suppressor and plays an important role in cancers of the liver, pancreas, endometrium of uterus, ovary, prostate, bladder and colon. The activation of Notch pathway plays a vital role in the progression of some cancer. In addition, Notch pathway activation was also shown to drive chemoresistance in cancer, as well. Chemotherapeutically, combined NOTCH1 inhibitor syner-gistically attenuated chemotherapy-enriched cancer stem cell population both in vitro and in vivo. This may prove to be beneficial in the treatment of cancer. Conclusion: The Notch inhibitors possess anti-proliferative effects on cancer, thereby serving as a new treatment for cancer.

Original languageEnglish
Pages (from-to)128-143
Number of pages16
JournalCurrent Drug Targets
Volume19
Issue number2
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Tumors
Chemical activation
Notch Receptors
Neoplasms
Mammals
Chemotherapy
Cell proliferation
Stem cells
Liver
Therapeutics
Ligands
Neoplastic Stem Cells
Liver Neoplasms
Endometrium
Pancreatic Neoplasms
Oncogenes
Uterus
Embryonic Development
Prostate
Cell Differentiation

Keywords

  • Cancer
  • Cell proliferation
  • Embryonic development
  • Inhibitors
  • Notch pathway
  • Signalling
  • Treatment

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Notch signalling pathways and their importance in the treatment of cancers. / Teoh, Seong Lin; Das, Srijit.

In: Current Drug Targets, Vol. 19, No. 2, 01.01.2018, p. 128-143.

Research output: Contribution to journalReview article

@article{0eaed326a0dd495db27cf6fb727a3b6e,
title = "Notch signalling pathways and their importance in the treatment of cancers",
abstract = "Background: The Notch pathway is an evolutionarily conserved, intercellular signalling system which is present in all multicellular organisms and mammals. The Notch pathway plays an important role in the embryonic development as it controls cell proliferation, cell differentiation and binary cell fate decisions. Objective: In the present review, we highlight the Notch signalling pathway components i.e. Notch receptors, ligands, effector, and their regulators. We also discuss the tumor biology of the Notch pathway involved in various cancers. Results: Interestingly, the Notch signalling pathway is dysregulated in many cancers. Notch may serve as oncogene or tumor suppressor and plays an important role in cancers of the liver, pancreas, endometrium of uterus, ovary, prostate, bladder and colon. The activation of Notch pathway plays a vital role in the progression of some cancer. In addition, Notch pathway activation was also shown to drive chemoresistance in cancer, as well. Chemotherapeutically, combined NOTCH1 inhibitor syner-gistically attenuated chemotherapy-enriched cancer stem cell population both in vitro and in vivo. This may prove to be beneficial in the treatment of cancer. Conclusion: The Notch inhibitors possess anti-proliferative effects on cancer, thereby serving as a new treatment for cancer.",
keywords = "Cancer, Cell proliferation, Embryonic development, Inhibitors, Notch pathway, Signalling, Treatment",
author = "Teoh, {Seong Lin} and Srijit Das",
year = "2018",
month = "1",
day = "1",
doi = "10.2174/1389450118666170309143419",
language = "English",
volume = "19",
pages = "128--143",
journal = "Current Drug Targets",
issn = "1389-4501",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - Notch signalling pathways and their importance in the treatment of cancers

AU - Teoh, Seong Lin

AU - Das, Srijit

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The Notch pathway is an evolutionarily conserved, intercellular signalling system which is present in all multicellular organisms and mammals. The Notch pathway plays an important role in the embryonic development as it controls cell proliferation, cell differentiation and binary cell fate decisions. Objective: In the present review, we highlight the Notch signalling pathway components i.e. Notch receptors, ligands, effector, and their regulators. We also discuss the tumor biology of the Notch pathway involved in various cancers. Results: Interestingly, the Notch signalling pathway is dysregulated in many cancers. Notch may serve as oncogene or tumor suppressor and plays an important role in cancers of the liver, pancreas, endometrium of uterus, ovary, prostate, bladder and colon. The activation of Notch pathway plays a vital role in the progression of some cancer. In addition, Notch pathway activation was also shown to drive chemoresistance in cancer, as well. Chemotherapeutically, combined NOTCH1 inhibitor syner-gistically attenuated chemotherapy-enriched cancer stem cell population both in vitro and in vivo. This may prove to be beneficial in the treatment of cancer. Conclusion: The Notch inhibitors possess anti-proliferative effects on cancer, thereby serving as a new treatment for cancer.

AB - Background: The Notch pathway is an evolutionarily conserved, intercellular signalling system which is present in all multicellular organisms and mammals. The Notch pathway plays an important role in the embryonic development as it controls cell proliferation, cell differentiation and binary cell fate decisions. Objective: In the present review, we highlight the Notch signalling pathway components i.e. Notch receptors, ligands, effector, and their regulators. We also discuss the tumor biology of the Notch pathway involved in various cancers. Results: Interestingly, the Notch signalling pathway is dysregulated in many cancers. Notch may serve as oncogene or tumor suppressor and plays an important role in cancers of the liver, pancreas, endometrium of uterus, ovary, prostate, bladder and colon. The activation of Notch pathway plays a vital role in the progression of some cancer. In addition, Notch pathway activation was also shown to drive chemoresistance in cancer, as well. Chemotherapeutically, combined NOTCH1 inhibitor syner-gistically attenuated chemotherapy-enriched cancer stem cell population both in vitro and in vivo. This may prove to be beneficial in the treatment of cancer. Conclusion: The Notch inhibitors possess anti-proliferative effects on cancer, thereby serving as a new treatment for cancer.

KW - Cancer

KW - Cell proliferation

KW - Embryonic development

KW - Inhibitors

KW - Notch pathway

KW - Signalling

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=85042142802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042142802&partnerID=8YFLogxK

U2 - 10.2174/1389450118666170309143419

DO - 10.2174/1389450118666170309143419

M3 - Review article

VL - 19

SP - 128

EP - 143

JO - Current Drug Targets

JF - Current Drug Targets

SN - 1389-4501

IS - 2

ER -