Noncytotoxic and antitumour-promoting activities of garcinia acid esters from Garcinia atroviridis Griff. ex T. Anders (Guttiferae)

Muhammad Mukram Mohamed Mackeen, Lim Y. Mooi, Mohidin Amran, Nashriyah Mat, Nordin H. Lajis, Abdul M. Ali

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The in vitro antitumour-promoting, cytotoxic, and antioxidant activities of two ester derivatives of garcinia acid, that is, 2-(butoxycarbonylmethyl)-3- butoxycarbonyl-2-hydroxy-3-propanolide (1) and 1′,1′′-dibutyl methyl hydroxycitrate (2), that had been previously isolated from the fruits of Garcinia atroviridis Griff. ex T. Anders (Guttiferae), were examined. Based on the inhibition of Epstein-Barr virus early antigen (EBV-EA) activation, compound 1 (IC50: 70M) showed much higher (8-fold) antitumour-promoting activity than compound 2 (IC50: 560M). In addition, both compounds were nontoxic towards CEM-SS (human T-lymphoblastic leukemia) cells (CD50: 100M), Raji (human B-lymphoblastoid) cells (CD50: 600M), and brine shrimp (LD50: 300M). Although the antitumour-promoting activity of compound 1 is moderate compared with the known antitumour promoter genistein, its non-toxicity suggests the potential of compound 1 and related structures as chemopreventive agents. The weak antioxidant activity displayed by both compounds also suggested that the primary antitumour-promoting mechanism of compound 1 did not involve oxidative-stress quenching.

Original languageEnglish
Article number829814
JournalEvidence-based Complementary and Alternative Medicine
Volume2012
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Garcinia
Inhibitory Concentration 50
Esters
Antioxidants
Propiolactone
T-Cell Leukemia
Artemia
Genistein
Lethal Dose 50
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fruit
Oxidative Stress
hydroxycitric acid

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Noncytotoxic and antitumour-promoting activities of garcinia acid esters from Garcinia atroviridis Griff. ex T. Anders (Guttiferae). / Mohamed Mackeen, Muhammad Mukram; Mooi, Lim Y.; Amran, Mohidin; Mat, Nashriyah; Lajis, Nordin H.; Ali, Abdul M.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2012, 829814, 2012.

Research output: Contribution to journalArticle

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