Non-secretory multiple myeloma with diagnostic challenges

Noor Hamidah Hussin, Raja Zahratul Azma Raja Sabudin, E. Ezalia, Srijit Das, N. A. Umar, M. Swaminathan, Zahiah Mohamed, S Fadilah S. Abdul Wahid

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Non-secretory multiple myeloma (NSMM) is a rare variant of the classic form of multiple myeloma (MM). In NSMM, no monoclonal gammopathy can be detected in serum or urine by conventional techniques, making the diagnosis more difficult. We describe a 71-year-old man who had been diagnosed and treated for granulocytic sarcoma one year prior to his recent problems of progressive low-back pain of two months duration. Skeletal X-rays showed diffuse osteolytic lesions with multiple pathological fractures but there was no monoclonal gammopathy in the serum or urine. The biopsy of the lytic lesion on the upper part of the femur showed infiltration by abnormal plasma cells. A diagnosis of NSMM was made and he was treated with chemotherapy. The early diagnostic difficulty and the challenges faced regarding the case are discussed.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalClinica Terapeutica
Volume161
Issue number5
Publication statusPublished - Sep 2010

Fingerprint

Multiple Myeloma
Paraproteinemias
Urine
Myeloid Sarcoma
Spontaneous Fractures
Low Back Pain
Plasma Cells
Serum
Femur
X-Rays
Biopsy
Drug Therapy

Keywords

  • Diagnosis
  • Multiple myeloma
  • Non-secretory
  • Osteolytic lesions
  • Pathological fracture

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Non-secretory multiple myeloma with diagnostic challenges. / Hussin, Noor Hamidah; Raja Sabudin, Raja Zahratul Azma; Ezalia, E.; Das, Srijit; Umar, N. A.; Swaminathan, M.; Mohamed, Zahiah; S. Abdul Wahid, S Fadilah.

In: Clinica Terapeutica, Vol. 161, No. 5, 09.2010, p. 445-448.

Research output: Contribution to journalArticle

Hussin, NH, Raja Sabudin, RZA, Ezalia, E, Das, S, Umar, NA, Swaminathan, M, Mohamed, Z & S. Abdul Wahid, SF 2010, 'Non-secretory multiple myeloma with diagnostic challenges', Clinica Terapeutica, vol. 161, no. 5, pp. 445-448.
Hussin NH, Raja Sabudin RZA, Ezalia E, Das S, Umar NA, Swaminathan M et al. Non-secretory multiple myeloma with diagnostic challenges. Clinica Terapeutica. 2010 Sep;161(5):445-448.
Hussin, Noor Hamidah ; Raja Sabudin, Raja Zahratul Azma ; Ezalia, E. ; Das, Srijit ; Umar, N. A. ; Swaminathan, M. ; Mohamed, Zahiah ; S. Abdul Wahid, S Fadilah. / Non-secretory multiple myeloma with diagnostic challenges. In: Clinica Terapeutica. 2010 ; Vol. 161, No. 5. pp. 445-448.
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