Non-dermatophytic moulds and yeasts as agents of onychomycosis in a Malaysian medical centre

Research output: Contribution to journalArticle

Abstract

Objective: Onychomycosis can be caused by numerous fungi, with geographical and temporal factors influencing the prevalence of the various aetiological agents. We set out to identify and classify the various fungi cultured from the nail clippings of patients diagnosed with onychomycosis in UKM Medical Centre, Malaysia. Methods: This retrospective study involved cases of onychomycosis diagnosed from January 2013 to July 2014. For each fungus, mycological diagnosis was achieved by direct microscopic examination of the nail clipping(s) followed by morphological identification of the fungus following culture on various artificial media. Results: A total of 180 fungal isolates were cultured from the nail clippings of 146 different patients. Non-dermatophytic moulds accounted for most of the fungal isolates (59.8%), followed by yeasts (35.7%) and dermatophytes (4.5%). Overall, Candida was the most frequently isolated fungal genus and Aspergillus was the most frequently cultured mould genus. Out of the three dermatophyte genera, two (Microsporum and Trichophyton) were isolated. Conclusion: In our centre, non-dermatophytic moulds and yeasts are a lot more prevalent as causative agents of onychomycosis than dermatophytes.

Original languageEnglish
Pages (from-to)380-383
Number of pages4
JournalBangladesh Journal of Medical Science
Volume16
Issue number3
DOIs
Publication statusPublished - 2017

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Onychomycosis
Fungi
Yeasts
Arthrodermataceae
Nails
Microsporum
Trichophyton
Malaysia
Aspergillus
Candida
Retrospective Studies

Keywords

  • Dermatophyte
  • Nail clipping
  • Non-dermatophytic mould
  • Onychomycosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Non-dermatophytic moulds and yeasts as agents of onychomycosis in a Malaysian medical centre",
abstract = "Objective: Onychomycosis can be caused by numerous fungi, with geographical and temporal factors influencing the prevalence of the various aetiological agents. We set out to identify and classify the various fungi cultured from the nail clippings of patients diagnosed with onychomycosis in UKM Medical Centre, Malaysia. Methods: This retrospective study involved cases of onychomycosis diagnosed from January 2013 to July 2014. For each fungus, mycological diagnosis was achieved by direct microscopic examination of the nail clipping(s) followed by morphological identification of the fungus following culture on various artificial media. Results: A total of 180 fungal isolates were cultured from the nail clippings of 146 different patients. Non-dermatophytic moulds accounted for most of the fungal isolates (59.8{\%}), followed by yeasts (35.7{\%}) and dermatophytes (4.5{\%}). Overall, Candida was the most frequently isolated fungal genus and Aspergillus was the most frequently cultured mould genus. Out of the three dermatophyte genera, two (Microsporum and Trichophyton) were isolated. Conclusion: In our centre, non-dermatophytic moulds and yeasts are a lot more prevalent as causative agents of onychomycosis than dermatophytes.",
keywords = "Dermatophyte, Nail clipping, Non-dermatophytic mould, Onychomycosis",
author = "Ding, {Chuan Hun} and Rahman, {Md. Mostafizur} and Khaithir, {Tzar Mohd Nizam} and Hamidah Yusoff and Hartini Satim",
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AU - Ding, Chuan Hun

AU - Rahman, Md. Mostafizur

AU - Khaithir, Tzar Mohd Nizam

AU - Yusoff, Hamidah

AU - Satim, Hartini

PY - 2017

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AB - Objective: Onychomycosis can be caused by numerous fungi, with geographical and temporal factors influencing the prevalence of the various aetiological agents. We set out to identify and classify the various fungi cultured from the nail clippings of patients diagnosed with onychomycosis in UKM Medical Centre, Malaysia. Methods: This retrospective study involved cases of onychomycosis diagnosed from January 2013 to July 2014. For each fungus, mycological diagnosis was achieved by direct microscopic examination of the nail clipping(s) followed by morphological identification of the fungus following culture on various artificial media. Results: A total of 180 fungal isolates were cultured from the nail clippings of 146 different patients. Non-dermatophytic moulds accounted for most of the fungal isolates (59.8%), followed by yeasts (35.7%) and dermatophytes (4.5%). Overall, Candida was the most frequently isolated fungal genus and Aspergillus was the most frequently cultured mould genus. Out of the three dermatophyte genera, two (Microsporum and Trichophyton) were isolated. Conclusion: In our centre, non-dermatophytic moulds and yeasts are a lot more prevalent as causative agents of onychomycosis than dermatophytes.

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