Nocturia in patients with benign prostatic hyperplasia

Evaluating the significance of ageing, co-morbid illnesses, lifestyle and medical therapy in treatment outcome in real life practice

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aim: The aim of study was to evaluate the influence of ageing, lifestyle, and co morbid illnesses on treatment outcome of nocturia among men with BPH. Methods: Patients with BPH on medical therapy of least 6 months and up to 48 months were interviewed. Nocturia episodes, co morbid illnesses, beverage intake frequency, medications and work history were documented. Body Mass Index (BMI), waist circumference (WC), prostate volume, and prostate specific antigen (PSA) were recorded. Treatment failure is defined as persistent nocturia despite on medical therapy for BPH. Results: In 156 patients, the prevalence of nocturia was 96.7% while nocturia of 2 or more was 85.9%. Factors associated with treatment failure was older age (p<0.01), usage of diuretics (p=0.03), and antimuscarinics (p<0.01), while active working status (p<0.01), use of desmopression (p=0.01), and increased coffee intake (p=0.02) were associated with nocturia improvement. Co-morbid illnesses, obesity, WC, alcohol intake, PSA, prostate volume, and use of BPH medical therapy did not influence treatment outcome. Conclusion: Advancing age has a significance negative outcome on nocturia treatment, while standard BPH medical therapy and co morbid illnesses have an insignificant impact. However, alleviation of bothersome symptoms is possible with the understanding of its patho-physiology and individual-based approach to treatment and expected outcome.

Original languageEnglish
Pages (from-to)112-117
Number of pages6
JournalAging Male
Volume18
Issue number2
DOIs
Publication statusPublished - 1 Jun 2015

Fingerprint

Nocturia
Prostatic Hyperplasia
Life Style
Waist Circumference
Prostate-Specific Antigen
Treatment Failure
Therapeutics
Prostate
Muscarinic Antagonists
Morbid Obesity
Coffee
Beverages
Diuretics
Body Mass Index
Alcohols

Keywords

  • Malaysia
  • Nocturia
  • Prevalence
  • Prostate

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

@article{caae7ba598754c73a4b39b4a5c9e57f0,
title = "Nocturia in patients with benign prostatic hyperplasia: Evaluating the significance of ageing, co-morbid illnesses, lifestyle and medical therapy in treatment outcome in real life practice",
abstract = "Aim: The aim of study was to evaluate the influence of ageing, lifestyle, and co morbid illnesses on treatment outcome of nocturia among men with BPH. Methods: Patients with BPH on medical therapy of least 6 months and up to 48 months were interviewed. Nocturia episodes, co morbid illnesses, beverage intake frequency, medications and work history were documented. Body Mass Index (BMI), waist circumference (WC), prostate volume, and prostate specific antigen (PSA) were recorded. Treatment failure is defined as persistent nocturia despite on medical therapy for BPH. Results: In 156 patients, the prevalence of nocturia was 96.7{\%} while nocturia of 2 or more was 85.9{\%}. Factors associated with treatment failure was older age (p<0.01), usage of diuretics (p=0.03), and antimuscarinics (p<0.01), while active working status (p<0.01), use of desmopression (p=0.01), and increased coffee intake (p=0.02) were associated with nocturia improvement. Co-morbid illnesses, obesity, WC, alcohol intake, PSA, prostate volume, and use of BPH medical therapy did not influence treatment outcome. Conclusion: Advancing age has a significance negative outcome on nocturia treatment, while standard BPH medical therapy and co morbid illnesses have an insignificant impact. However, alleviation of bothersome symptoms is possible with the understanding of its patho-physiology and individual-based approach to treatment and expected outcome.",
keywords = "Malaysia, Nocturia, Prevalence, Prostate",
author = "Praveen Singam and Goh, {Eng Hong} and Ho, {Chee Kong Christopher} and Tan, {Guan Hee} and Jasman, {Mohd Hafidzul} and Fam, {Xeng Inn} and Badrulhisham Bahadzor and {Mohd. Tamil}, Azmi and {Md. Zainuddin}, Zulkifli",
year = "2015",
month = "6",
day = "1",
doi = "10.3109/13685538.2015.1011614",
language = "English",
volume = "18",
pages = "112--117",
journal = "Aging Male",
issn = "1368-5538",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Nocturia in patients with benign prostatic hyperplasia

T2 - Evaluating the significance of ageing, co-morbid illnesses, lifestyle and medical therapy in treatment outcome in real life practice

AU - Singam, Praveen

AU - Goh, Eng Hong

AU - Ho, Chee Kong Christopher

AU - Tan, Guan Hee

AU - Jasman, Mohd Hafidzul

AU - Fam, Xeng Inn

AU - Bahadzor, Badrulhisham

AU - Mohd. Tamil, Azmi

AU - Md. Zainuddin, Zulkifli

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Aim: The aim of study was to evaluate the influence of ageing, lifestyle, and co morbid illnesses on treatment outcome of nocturia among men with BPH. Methods: Patients with BPH on medical therapy of least 6 months and up to 48 months were interviewed. Nocturia episodes, co morbid illnesses, beverage intake frequency, medications and work history were documented. Body Mass Index (BMI), waist circumference (WC), prostate volume, and prostate specific antigen (PSA) were recorded. Treatment failure is defined as persistent nocturia despite on medical therapy for BPH. Results: In 156 patients, the prevalence of nocturia was 96.7% while nocturia of 2 or more was 85.9%. Factors associated with treatment failure was older age (p<0.01), usage of diuretics (p=0.03), and antimuscarinics (p<0.01), while active working status (p<0.01), use of desmopression (p=0.01), and increased coffee intake (p=0.02) were associated with nocturia improvement. Co-morbid illnesses, obesity, WC, alcohol intake, PSA, prostate volume, and use of BPH medical therapy did not influence treatment outcome. Conclusion: Advancing age has a significance negative outcome on nocturia treatment, while standard BPH medical therapy and co morbid illnesses have an insignificant impact. However, alleviation of bothersome symptoms is possible with the understanding of its patho-physiology and individual-based approach to treatment and expected outcome.

AB - Aim: The aim of study was to evaluate the influence of ageing, lifestyle, and co morbid illnesses on treatment outcome of nocturia among men with BPH. Methods: Patients with BPH on medical therapy of least 6 months and up to 48 months were interviewed. Nocturia episodes, co morbid illnesses, beverage intake frequency, medications and work history were documented. Body Mass Index (BMI), waist circumference (WC), prostate volume, and prostate specific antigen (PSA) were recorded. Treatment failure is defined as persistent nocturia despite on medical therapy for BPH. Results: In 156 patients, the prevalence of nocturia was 96.7% while nocturia of 2 or more was 85.9%. Factors associated with treatment failure was older age (p<0.01), usage of diuretics (p=0.03), and antimuscarinics (p<0.01), while active working status (p<0.01), use of desmopression (p=0.01), and increased coffee intake (p=0.02) were associated with nocturia improvement. Co-morbid illnesses, obesity, WC, alcohol intake, PSA, prostate volume, and use of BPH medical therapy did not influence treatment outcome. Conclusion: Advancing age has a significance negative outcome on nocturia treatment, while standard BPH medical therapy and co morbid illnesses have an insignificant impact. However, alleviation of bothersome symptoms is possible with the understanding of its patho-physiology and individual-based approach to treatment and expected outcome.

KW - Malaysia

KW - Nocturia

KW - Prevalence

KW - Prostate

UR - http://www.scopus.com/inward/record.url?scp=84931048960&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931048960&partnerID=8YFLogxK

U2 - 10.3109/13685538.2015.1011614

DO - 10.3109/13685538.2015.1011614

M3 - Article

VL - 18

SP - 112

EP - 117

JO - Aging Male

JF - Aging Male

SN - 1368-5538

IS - 2

ER -