Nitrofurantoin-induced hepatic and pulmonary biochemical changes in mice fed different vitamin E doses

Aishah Adam, Alini Marzuki, Wan Zurinah Wan Ngah, Gapor Md Top

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    The hepatic and pulmonary effects of nitrofurantoin (40 mg/kg, intraperitoneally) were determined at 4 and 24 hr following its administration in mice fed for 10 weeks with a vitamin E sufficient, deficient or enriched diet. Liver glutathione (GSH) was reduced by nitrofurantoin at 4 hr but was unchanged 20 hr later. Nitrofurantoin did not affect liver glutathione peroxidase, glutathione reductase or superoxide dismutase activities,liver catalase activities were decreased by nitrofurantoin at 4 hr. Lung GSH levels were increased whilst glutathione peroxidase activity was decreased at 4 and 24 hr. Lung glutathione reductase activity was reduced in certain groups. Nitrofurantoin did not affect lung superoxide dismutase, but catalase was decreased at 24 hr. Liver malondialdehyde levels were increased by nitrofurantoin in the vitamin E deficient group whilst lung malondialdehyde levels remained unchanged. Both liver and lung malondialdehyde levels were unaffected by vitamin E supplementation when compared to the vitamin E-sufficient group. These results suggest that nitrofurantoin (40 mg/kg) was deleterious to the liver and lung. Nitrofurantoin-induced lipid peroxidation was seen in vitamin E deficiency but an increase in dietary vitamin E content did not provide additional protection compared to the recommended daily allowance. The antioxidant activities of α-tocopherol and γ-enriched tocotrienol were similar.

    Original languageEnglish
    Pages (from-to)334-339
    Number of pages6
    JournalPharmacology and Toxicology
    Volume79
    Issue number6
    Publication statusPublished - 1996

    Fingerprint

    Nitrofurantoin
    Vitamin E
    Liver
    Lung
    Malondialdehyde
    Glutathione Reductase
    Glutathione Peroxidase
    Catalase
    Superoxide Dismutase
    Tocotrienols
    Vitamin E Deficiency
    Recommended Dietary Allowances
    Tocopherols
    Nutrition
    Lipid Peroxidation
    Glutathione
    Antioxidants
    Diet
    Lipids

    ASJC Scopus subject areas

    • Pharmacology
    • Toxicology
    • Health, Toxicology and Mutagenesis

    Cite this

    Nitrofurantoin-induced hepatic and pulmonary biochemical changes in mice fed different vitamin E doses. / Adam, Aishah; Marzuki, Alini; Ngah, Wan Zurinah Wan; Top, Gapor Md.

    In: Pharmacology and Toxicology, Vol. 79, No. 6, 1996, p. 334-339.

    Research output: Contribution to journalArticle

    Adam, Aishah ; Marzuki, Alini ; Ngah, Wan Zurinah Wan ; Top, Gapor Md. / Nitrofurantoin-induced hepatic and pulmonary biochemical changes in mice fed different vitamin E doses. In: Pharmacology and Toxicology. 1996 ; Vol. 79, No. 6. pp. 334-339.
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