Nine different glucose-6-phosphate dehydrogenase (G6PD) variants in a Malaysian population with Malay, Chinese, Indian and Orang Asli (Aboriginal Malaysian) backgrounds

Jichun Wang, Enjie Luo, Makoto Hirai, Meiji Arai, Encik Abdul Salim Abdul Manand, Zaleha Md Isa, Noor Ishak Hidayah, Hiroyuki Matsuoka

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The Malaysian people consist of several ethnic groups including the Malay, the Chinese, the Indian and the Orang Ash (aboriginal Malaysians). We collected blood samples from outpatients of 2 hospitals in the State of Selangor and identified 27 glucose-6-phosphate dehydrogenase (G6PD)-deficient subjects among these ethnic groups. In the Malay, G6PD Viangchan (871G > A, 1311C > T, IVS11 nt93T > C) and G6PD Mahidol (487G > A) types, which are common in Cambodia and Myanmar, respectively, were detected. The Malay also had both subtypes of G6PD Mediterranean: the Mediterranean subtype (563C > T, 1311C > T, LVS11 nt93T > C) and the Indo-Pakistan subtype (563C > T, 1311C, IVS11 nt93T). In Malaysians of Chinese background, G6PD Kaiping (1388G > A), G6PD Canton (1376G > T) and G6PD Gaohe (95A > G), which are common in China, were detected. Indian Malaysians possessed G6PD Mediterranean (Indo-Pakistan subtype) and G6PD Namoru (208T > C), a few cases of which had been reported in Vanuatu and many in India. Our findings indicate that G6PD Namoru occurs in India and flows to Malaysia up to Vanuatu. We also discovered 5 G6PD-deficient cases with 2 nucleotide substitutions of 1311C > T and IVS11 nt93T > C, but without amino-acid substitution in the G6PD molecule. These results indicate that the Malaysian people have incorporated many ancestors in terms of G6PD variants. Copyright

Original languageEnglish
Article number7
JournalActa Medica Okayama
Volume62
Issue number5
Publication statusPublished - Oct 2008

Fingerprint

Glucosephosphate Dehydrogenase
Population
Vanuatu
Pakistan
Ashes
Ethnic Groups
India
Substitution reactions
Myanmar
Cambodia
State Hospitals
Malaysia
Amino Acid Substitution
China
Blood
Outpatients
Nucleotides

Keywords

  • Aborigine
  • Chinese
  • Glucose-6-phosphate dehydrogenase
  • Indian
  • Malay

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nine different glucose-6-phosphate dehydrogenase (G6PD) variants in a Malaysian population with Malay, Chinese, Indian and Orang Asli (Aboriginal Malaysian) backgrounds. / Wang, Jichun; Luo, Enjie; Hirai, Makoto; Arai, Meiji; Manand, Encik Abdul Salim Abdul; Md Isa, Zaleha; Hidayah, Noor Ishak; Matsuoka, Hiroyuki.

In: Acta Medica Okayama, Vol. 62, No. 5, 7, 10.2008.

Research output: Contribution to journalArticle

Wang, Jichun ; Luo, Enjie ; Hirai, Makoto ; Arai, Meiji ; Manand, Encik Abdul Salim Abdul ; Md Isa, Zaleha ; Hidayah, Noor Ishak ; Matsuoka, Hiroyuki. / Nine different glucose-6-phosphate dehydrogenase (G6PD) variants in a Malaysian population with Malay, Chinese, Indian and Orang Asli (Aboriginal Malaysian) backgrounds. In: Acta Medica Okayama. 2008 ; Vol. 62, No. 5.
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abstract = "The Malaysian people consist of several ethnic groups including the Malay, the Chinese, the Indian and the Orang Ash (aboriginal Malaysians). We collected blood samples from outpatients of 2 hospitals in the State of Selangor and identified 27 glucose-6-phosphate dehydrogenase (G6PD)-deficient subjects among these ethnic groups. In the Malay, G6PD Viangchan (871G > A, 1311C > T, IVS11 nt93T > C) and G6PD Mahidol (487G > A) types, which are common in Cambodia and Myanmar, respectively, were detected. The Malay also had both subtypes of G6PD Mediterranean: the Mediterranean subtype (563C > T, 1311C > T, LVS11 nt93T > C) and the Indo-Pakistan subtype (563C > T, 1311C, IVS11 nt93T). In Malaysians of Chinese background, G6PD Kaiping (1388G > A), G6PD Canton (1376G > T) and G6PD Gaohe (95A > G), which are common in China, were detected. Indian Malaysians possessed G6PD Mediterranean (Indo-Pakistan subtype) and G6PD Namoru (208T > C), a few cases of which had been reported in Vanuatu and many in India. Our findings indicate that G6PD Namoru occurs in India and flows to Malaysia up to Vanuatu. We also discovered 5 G6PD-deficient cases with 2 nucleotide substitutions of 1311C > T and IVS11 nt93T > C, but without amino-acid substitution in the G6PD molecule. These results indicate that the Malaysian people have incorporated many ancestors in terms of G6PD variants. Copyright",
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AU - Luo, Enjie

AU - Hirai, Makoto

AU - Arai, Meiji

AU - Manand, Encik Abdul Salim Abdul

AU - Md Isa, Zaleha

AU - Hidayah, Noor Ishak

AU - Matsuoka, Hiroyuki

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AB - The Malaysian people consist of several ethnic groups including the Malay, the Chinese, the Indian and the Orang Ash (aboriginal Malaysians). We collected blood samples from outpatients of 2 hospitals in the State of Selangor and identified 27 glucose-6-phosphate dehydrogenase (G6PD)-deficient subjects among these ethnic groups. In the Malay, G6PD Viangchan (871G > A, 1311C > T, IVS11 nt93T > C) and G6PD Mahidol (487G > A) types, which are common in Cambodia and Myanmar, respectively, were detected. The Malay also had both subtypes of G6PD Mediterranean: the Mediterranean subtype (563C > T, 1311C > T, LVS11 nt93T > C) and the Indo-Pakistan subtype (563C > T, 1311C, IVS11 nt93T). In Malaysians of Chinese background, G6PD Kaiping (1388G > A), G6PD Canton (1376G > T) and G6PD Gaohe (95A > G), which are common in China, were detected. Indian Malaysians possessed G6PD Mediterranean (Indo-Pakistan subtype) and G6PD Namoru (208T > C), a few cases of which had been reported in Vanuatu and many in India. Our findings indicate that G6PD Namoru occurs in India and flows to Malaysia up to Vanuatu. We also discovered 5 G6PD-deficient cases with 2 nucleotide substitutions of 1311C > T and IVS11 nt93T > C, but without amino-acid substitution in the G6PD molecule. These results indicate that the Malaysian people have incorporated many ancestors in terms of G6PD variants. Copyright

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KW - Indian

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