Nigella sativa and its protective role in oxidative stress and hypertension

Xin Fang Leong, Mohd Rais Mustafa, Kamsiah Jaarin

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Hypertension increases the risk for a variety of cardiovascular diseases, including stroke, coronary artery disease, heart failure, and peripheral vascular disease. The increase in oxidative stress has been associated with the pathogenesis of hypertension. Increase of blood pressure is due to an imbalance between antioxidants defence mechanisms and free radical productions. Excessive production of reactive oxygen species reduces nitric oxide bioavailability leading to an endothelial dysfunction and a subsequent increase in total peripheral resistance. Hypertension can cause few symptoms until it reaches the advanced stage and poses serious health problems with lifelong consequences. Hypertensive patients are required to take drugs for life to control the hypertension and prevent complications. Some of these drugs are expensive and may have adverse reactions. Hence, it is timely to examine scientifically, complimentary therapies that are more effective and with minimal undesirable effects. Nigella sativa (NS) and its active constituents have been documented to exhibit antioxidant, hypotensive, calcium channel blockade and diuretic properties which may contribute to reduce blood pressure. This suggests a potential role of NS in the management of hypertension, and thus more studies should be conducted to evaluate its effectiveness.

Original languageEnglish
Article number120732
JournalEvidence-based Complementary and Alternative Medicine
Volume2013
DOIs
Publication statusPublished - 2013

Fingerprint

Nigella sativa
Oxidative Stress
Hypertension
Antioxidants
Blood Pressure
Peripheral Vascular Diseases
Calcium Channels
Diuretics
Pharmaceutical Preparations
Vascular Resistance
Biological Availability
Free Radicals
Coronary Artery Disease
Reactive Oxygen Species
Nitric Oxide
Cardiovascular Diseases
Heart Failure
Stroke
Health

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Nigella sativa and its protective role in oxidative stress and hypertension. / Leong, Xin Fang; Rais Mustafa, Mohd; Jaarin, Kamsiah.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2013, 120732, 2013.

Research output: Contribution to journalArticle

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