New tigliane-type diterpenoids from Euphorbia aellenii Rech. F. with immunomodulatory activity

M. Ghanadian, A. M. Ayatollahi, Osman Mesaik Mohammed Ahmed Hassan, S. Afsharypour, O. M. Abdalla, F. Kobarfard

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The cytotoxic chloroform fraction of Euphorbia aellenii Rech. F. (Euphorbiaceae) afforded two new phorbol diterpenoids: 4-deoxy-4α-phorbol-12-(2,3-dimethyl) butyrate-13-isobutyrate and 17-hydroxy-4-deoxy-4α-phorbol-12-(2,3-dimethyl) butyrate-13-isobutyrate. Their structures were elucidated by NMR and other spectroscopic methods. The immunomodulating potentials of the isolated compounds were tested using standard proliferation and chemiluminescence assays. Compound 2 showed moderate inhibitory activity against both T-cell proliferation and reactive oxygen species (ROS) production in whole blood with IC50 of 14.0 ± 0.57 and 44.1 ± 3.8 μg/ml, respectively, while compound 1 was relatively inactive with IC50 >50 μg/mL for T-cell proliferation, and >100 μg/mL for ROS.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalResearch in Pharmaceutical Sciences
Volume6
Issue number1
Publication statusPublished - 1 Apr 2011
Externally publishedYes

Fingerprint

Euphorbia
Diterpenes
Isobutyrates
Butyrates
Inhibitory Concentration 50
Reactive Oxygen Species
Cell Proliferation
Euphorbiaceae
T-Lymphocytes
Chloroform
Luminescence
phorbol

Keywords

  • Euphorbia aellenii
  • Immunomodulatory activity
  • Phorbol diterpene
  • Tigliane-type diterpenoid

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Ghanadian, M., Ayatollahi, A. M., Mohammed Ahmed Hassan, O. M., Afsharypour, S., Abdalla, O. M., & Kobarfard, F. (2011). New tigliane-type diterpenoids from Euphorbia aellenii Rech. F. with immunomodulatory activity. Research in Pharmaceutical Sciences, 6(1), 35-41.

New tigliane-type diterpenoids from Euphorbia aellenii Rech. F. with immunomodulatory activity. / Ghanadian, M.; Ayatollahi, A. M.; Mohammed Ahmed Hassan, Osman Mesaik; Afsharypour, S.; Abdalla, O. M.; Kobarfard, F.

In: Research in Pharmaceutical Sciences, Vol. 6, No. 1, 01.04.2011, p. 35-41.

Research output: Contribution to journalArticle

Ghanadian, M, Ayatollahi, AM, Mohammed Ahmed Hassan, OM, Afsharypour, S, Abdalla, OM & Kobarfard, F 2011, 'New tigliane-type diterpenoids from Euphorbia aellenii Rech. F. with immunomodulatory activity', Research in Pharmaceutical Sciences, vol. 6, no. 1, pp. 35-41.
Ghanadian M, Ayatollahi AM, Mohammed Ahmed Hassan OM, Afsharypour S, Abdalla OM, Kobarfard F. New tigliane-type diterpenoids from Euphorbia aellenii Rech. F. with immunomodulatory activity. Research in Pharmaceutical Sciences. 2011 Apr 1;6(1):35-41.
Ghanadian, M. ; Ayatollahi, A. M. ; Mohammed Ahmed Hassan, Osman Mesaik ; Afsharypour, S. ; Abdalla, O. M. ; Kobarfard, F. / New tigliane-type diterpenoids from Euphorbia aellenii Rech. F. with immunomodulatory activity. In: Research in Pharmaceutical Sciences. 2011 ; Vol. 6, No. 1. pp. 35-41.
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